Bleeding tendency of both carriers and noncarriers according to decreasing clotting factor level
. | Clotting factor level . | . | . | . | ||
|---|---|---|---|---|---|---|
. | More than 0.60 IU/mL . | Between 0.41 and 0.60 IU/mL . | 0.40 IU/mL or below . | P for trend . | ||
| Small wounds | < .01 | |||||
| Event/total (%) | 28/233 (12) | 25/64 (39) | 11/60 (18) | |||
| RR (CI) | 1 | 3.3 (2.0-5.2) | 1.5 (0.8-2.9) | |||
| Joint bleeds | .06 | |||||
| Event/total (%) | 12/241 (5) | 9/65 (14) | 6/62 (10) | |||
| RR (CI) | 1 | 2.8 (1.2-6.3) | 1.9 (0.8-4.9) | |||
| Tonsillectomy | .06 | |||||
| Event/total (%) | 21/124 (17) | 6/26 (23) | 11/31 (35) | |||
| RR (CI) | 1 | 1.4 (0.6-3.0) | 2.1 (1.1-3.9) | |||
| Tooth extraction | < .01 | |||||
| Event/total (%) | 18/139 (13) | 14/51 (27) | 15/36 (42) | |||
| RR (CI) | 1 | 1.8 (1.0-3.0) | 2.5 (1.5-4.2) | |||
| Operations | < .01 | |||||
| Event/total (%) | 18/139 (13) | 14/49 (29) | 15/36 (42) | |||
| RR (CI) | 1 | 2.2 (1.2-4.1) | 3.2 (1.8-5.7) | |||
| Bleeding score 2 or above, RR (CI) | 1 | 3.0 (1.5-5.8) | 4.0 (2.1-7.7) | < .01 | ||
. | Clotting factor level . | . | . | . | ||
|---|---|---|---|---|---|---|
. | More than 0.60 IU/mL . | Between 0.41 and 0.60 IU/mL . | 0.40 IU/mL or below . | P for trend . | ||
| Small wounds | < .01 | |||||
| Event/total (%) | 28/233 (12) | 25/64 (39) | 11/60 (18) | |||
| RR (CI) | 1 | 3.3 (2.0-5.2) | 1.5 (0.8-2.9) | |||
| Joint bleeds | .06 | |||||
| Event/total (%) | 12/241 (5) | 9/65 (14) | 6/62 (10) | |||
| RR (CI) | 1 | 2.8 (1.2-6.3) | 1.9 (0.8-4.9) | |||
| Tonsillectomy | .06 | |||||
| Event/total (%) | 21/124 (17) | 6/26 (23) | 11/31 (35) | |||
| RR (CI) | 1 | 1.4 (0.6-3.0) | 2.1 (1.1-3.9) | |||
| Tooth extraction | < .01 | |||||
| Event/total (%) | 18/139 (13) | 14/51 (27) | 15/36 (42) | |||
| RR (CI) | 1 | 1.8 (1.0-3.0) | 2.5 (1.5-4.2) | |||
| Operations | < .01 | |||||
| Event/total (%) | 18/139 (13) | 14/49 (29) | 15/36 (42) | |||
| RR (CI) | 1 | 2.2 (1.2-4.1) | 3.2 (1.8-5.7) | |||
| Bleeding score 2 or above, RR (CI) | 1 | 3.0 (1.5-5.8) | 4.0 (2.1-7.7) | < .01 | ||
Women who ever received treatment with clotting factor concentration, tranexamic acid, or desmopressin before tooth extraction, tonsillectomy, or operations were excluded from the analysis.