Markers in the linkage region on chromosome 5 and single-marker LOD scores under a fully penetrant recessive model
. | . | . | Recombination fraction . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker . | Genetic, cM . | Sequence, Mb . | 0.00 . | 0.01 . | 0.03 . | 0.05 . | 0.10 . | 0.15 . | |||||
| D5S2500 | 69.2 | 58.7 | −∞ | −2.83 | −1.94 | −1.53 | −0.97 | −0.66 | |||||
| D5S424* | 82.0 | 76.2 | 2.41 | 2.35 | 2.24 | 2.13 | 1.85 | 1.57 | |||||
| D5S2041* | 82.0 | 76.7 | 1.20 | 1.17 | 1.11 | 1.05 | 0.90 | 0.75 | |||||
| D5S1501 | 85.2 | 78.5 | 2.20 | 2.15 | 2.04 | 1.93 | 1.66 | 1.39 | |||||
| D5S644 | 104.8 | 95.8 | 2.27 | 2.23 | 2.15 | 2.06 | 1.83 | 1.60 | |||||
| D5S2501 | 117.0 | 110.0 | 1.57 | 1.54 | 1.47 | 1.41 | 1.24 | 1.07 | |||||
| D5S1505 | 129.8 | 119.1 | 1.32 | 1.29 | 1.22 | 1.16 | 1.00 | 0.84 | |||||
| D5S1480 | 147.5 | 144.1 | −∞ | −3.66 | −2.34 | −1.73 | −0.94 | −0.54 | |||||
. | . | . | Recombination fraction . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker . | Genetic, cM . | Sequence, Mb . | 0.00 . | 0.01 . | 0.03 . | 0.05 . | 0.10 . | 0.15 . | |||||
| D5S2500 | 69.2 | 58.7 | −∞ | −2.83 | −1.94 | −1.53 | −0.97 | −0.66 | |||||
| D5S424* | 82.0 | 76.2 | 2.41 | 2.35 | 2.24 | 2.13 | 1.85 | 1.57 | |||||
| D5S2041* | 82.0 | 76.7 | 1.20 | 1.17 | 1.11 | 1.05 | 0.90 | 0.75 | |||||
| D5S1501 | 85.2 | 78.5 | 2.20 | 2.15 | 2.04 | 1.93 | 1.66 | 1.39 | |||||
| D5S644 | 104.8 | 95.8 | 2.27 | 2.23 | 2.15 | 2.06 | 1.83 | 1.60 | |||||
| D5S2501 | 117.0 | 110.0 | 1.57 | 1.54 | 1.47 | 1.41 | 1.24 | 1.07 | |||||
| D5S1505 | 129.8 | 119.1 | 1.32 | 1.29 | 1.22 | 1.16 | 1.00 | 0.84 | |||||
| D5S1480 | 147.5 | 144.1 | −∞ | −3.66 | −2.34 | −1.73 | −0.94 | −0.54 | |||||
The 6 rightmost column headings are recombination fractions between the putative disease gene and a marker. Genetic locations are from the Marshfield map.41
Markers were genotyped to prove that AP3B1 (at 77.3 Mb) lay inside the linkage interval.