Table 3. Clinical characteristics and... | American Society of Hematology

Table 3.

Clinical characteristics and outcome of patients with t(8;21) and TKD⁸¹⁶c-KIT mutations

No.	Age, y/sex	c-KIT mutation*	Cytogenetics*	WBC, × 10⁹/L*	EML†	Outcome§	OS, mo
1	47/M	D816Y	46,XY,t(8;21)(q22;q22), +4	46	Paraspinal mass (rel)	D/1st res rel	13
2	40/F	D816V	46,XX,t(8;21)(q22;q22)	21	Paraspinal mass (rel), sternal mass (rel)	D/2nd res rel	12
3	40/M	D816V	46,XY/46,XY,t(8;21)(q22;q22)	6.8	Paraspinal mass (rel)	D/2nd res rel	16
4	54/M	D816Y	46,XX,t(8;21)(q22;q22)	36	Skin (rel)	D/3rd res rel	19
5	40/M	D816V	46,XY,t(2;8;21)(q24;q22;q22)	72.5	Absent	D/prim ref	2
6	49/M	D816V	45,X, -Y,t(8;21)(q22;q22)	23.2	Absent	A/2nd CR	68
7	31/F	D816V	46,XX,t(8;21)(q22;q22)	15.2	Absent	D/1st res rel	14
8	16/M	D816V	46,XY,t(8;21)(q22;q22)/47,XY,t(8;21)(q22;q22),+13/46,XY	39.2	Absent	A/1st CR	82
9	50/M	D816V	46,XY,t(8;21)(q22;q22)	4.47	Absent	A/2nd CR	26
10	55/M	D816V	46,XX,t(8;21)(q22;q22)	157	Absent	D/1st res rel	57
11	26/M	D816Y	46,XY,t(8;21)(q22;q22)	165	Absent	D/1st res rel	10
12	57/F	D816Y	46,XY,t(8;21)(q22;q22)	3.5	Absent	D/early death	1

No.	Age, y/sex	c-KIT mutation*	Cytogenetics*	WBC, × 10⁹/L*	EML†	Outcome§	OS, mo
1	47/M	D816Y	46,XY,t(8;21)(q22;q22), +4	46	Paraspinal mass (rel)	D/1st res rel	13
2	40/F	D816V	46,XX,t(8;21)(q22;q22)	21	Paraspinal mass (rel), sternal mass (rel)	D/2nd res rel	12
3	40/M	D816V	46,XY/46,XY,t(8;21)(q22;q22)	6.8	Paraspinal mass (rel)	D/2nd res rel	16
4	54/M	D816Y	46,XX,t(8;21)(q22;q22)	36	Skin (rel)	D/3rd res rel	19
5	40/M	D816V	46,XY,t(2;8;21)(q24;q22;q22)	72.5	Absent	D/prim ref	2
6	49/M	D816V	45,X, -Y,t(8;21)(q22;q22)	23.2	Absent	A/2nd CR	68
7	31/F	D816V	46,XX,t(8;21)(q22;q22)	15.2	Absent	D/1st res rel	14
8	16/M	D816V	46,XY,t(8;21)(q22;q22)/47,XY,t(8;21)(q22;q22),+13/46,XY	39.2	Absent	A/1st CR	82
9	50/M	D816V	46,XY,t(8;21)(q22;q22)	4.47	Absent	A/2nd CR	26
10	55/M	D816V	46,XX,t(8;21)(q22;q22)	157	Absent	D/1st res rel	57
11	26/M	D816Y	46,XY,t(8;21)(q22;q22)	165	Absent	D/1st res rel	10
12	57/F	D816Y	46,XY,t(8;21)(q22;q22)	3.5	Absent	D/early death	1

Rel indicates at relapse; D, died; res rel, resistant relapse; A, alive; and prim ref, primary refractory.

At diagnosis.

Site and time of onset of EML.