Clinical and genetic characteristics at presentation of 67 patients with CBF AML
. | t(8;21) . | Inv(16) . | P . |
|---|---|---|---|
| Patients, no. | 42 | 25 | |
| Median age, y (range) | 40.5 (16-76) | 51 (17-88) | .097 |
| No. men/no. women | 28/14 | 18/7 | .855 |
| Median WBC, × 109/L (range) | 8.4 (2.1-165) | 14.6 (7.6-277) | .009 |
| Cytogenetic features | |||
| Without additional abnormalities | 26 | 18 | .400 |
| No. abnormalities | 9 | 4 | |
| Including +8 | 0 | 3 | |
| Including +22 | 0 | 1 | |
| Including LOS | 9 | 0 | |
| Structure abnormalities | 5 | 2 | |
| Including del(9q) | 3* | 0 | |
| Including del(7q) | 0 | 2† | |
| Other abnormalities | 2 | 1 | |
| c-KIT mutational status | |||
| c-KIT mutated cases, no. (%) | 19 (45.2) | 12 (48.0) | |
| TKD816 | 12 | 8 | .767 |
| Exon 8 | 5 | 3 | |
| Exon 11 | 2 | 0 | |
| V5301 | 0 | 1 |
. | t(8;21) . | Inv(16) . | P . |
|---|---|---|---|
| Patients, no. | 42 | 25 | |
| Median age, y (range) | 40.5 (16-76) | 51 (17-88) | .097 |
| No. men/no. women | 28/14 | 18/7 | .855 |
| Median WBC, × 109/L (range) | 8.4 (2.1-165) | 14.6 (7.6-277) | .009 |
| Cytogenetic features | |||
| Without additional abnormalities | 26 | 18 | .400 |
| No. abnormalities | 9 | 4 | |
| Including +8 | 0 | 3 | |
| Including +22 | 0 | 1 | |
| Including LOS | 9 | 0 | |
| Structure abnormalities | 5 | 2 | |
| Including del(9q) | 3* | 0 | |
| Including del(7q) | 0 | 2† | |
| Other abnormalities | 2 | 1 | |
| c-KIT mutational status | |||
| c-KIT mutated cases, no. (%) | 19 (45.2) | 12 (48.0) | |
| TKD816 | 12 | 8 | .767 |
| Exon 8 | 5 | 3 | |
| Exon 11 | 2 | 0 | |
| V5301 | 0 | 1 |