Baseline characteristics of subjects carriers of TLR4 polymorphisms Asp299Gly and Thr399Ile and subjects carriers of TLR4 wild-type
. | TLR4 wild type . | TLR4 polymorphisms . |
|---|---|---|
| Baseline characteristics and values | ||
| No. patients | 17 | 17 |
| Age, y, mean ± SEM | 56 ± 2.7 | 55 ± 2.7 |
| No. women (%) | 8 (47) | 8 (47) |
| Body mass index, kg/m2, mean ± SEM | 30 ± 1.7 | 31 ± 1.5 |
| Hypertension, no. (%) | 13 (76) | 12 (70) |
| Diabetes, no. (%) | 2 (10) | 2 (10) |
| LDL cholesterol level, mM | 3.65 ± 0.3, 3.88 (0.54-6.41) | 3.26 ± 0.7, 3.49 (1.55-4.06) |
| Fibrinogen level, g/L | 3.11 ± 0.19, 2.97 (2.14-4.16) | 3.13 ± 0.15, 3.00 (1.65-4.14) |
| MCP-1 level, pg/mL | 334 ± 22, 310 (206-546) | 350 ± 63, 255 (197-460) |
| sCD40L level, pg/mL | 547 ± 95, 276 (68-1122) | 468 ± 93, 443 (188-1200) |
| CRP level, mg/mL | 0.44 ± 0.07, 0.33 (0.02-0.93) | 0.48 ± 0.07, 0.41 (0.3-1.1) |
| sVCAM level, ng/mL | 697 ± 68, 625 (260-1301) | 465 ± 27, 473 (286-691)* |
| P-selectin level, ng/mL | 96 ± 8.6, 80 (51.6-163) | 79 ± 3.6, 80 (56-119) |
| 8-iso-PGF2α pg/mg creatinine level | 257 ± 39, 188 (89-520) | 279 ± 55, 228 (81-917) |
| IMT, mm | 1.2 ± 0.06, 1.2 (0.7-1.6) | 0.82 ± 0.02, 0.8 (0.7-1)† |
| Medications | ||
| Nitrates, no. (%) | 0 (0) | 1 (5) |
| β-Blockers, no. (%) | 1 (6) | 4 (24) |
| Calcium channel blockers, no. (%) | 4 (24) | 6 (35) |
| ACE inhibitors, no. (%) | 14 (82) | 9 (53) |
| Diuretics, no. (%) | 3 (18) | 5 (29) |
| Statins, no. (%) | 3 (18) | 3 (18) |
. | TLR4 wild type . | TLR4 polymorphisms . |
|---|---|---|
| Baseline characteristics and values | ||
| No. patients | 17 | 17 |
| Age, y, mean ± SEM | 56 ± 2.7 | 55 ± 2.7 |
| No. women (%) | 8 (47) | 8 (47) |
| Body mass index, kg/m2, mean ± SEM | 30 ± 1.7 | 31 ± 1.5 |
| Hypertension, no. (%) | 13 (76) | 12 (70) |
| Diabetes, no. (%) | 2 (10) | 2 (10) |
| LDL cholesterol level, mM | 3.65 ± 0.3, 3.88 (0.54-6.41) | 3.26 ± 0.7, 3.49 (1.55-4.06) |
| Fibrinogen level, g/L | 3.11 ± 0.19, 2.97 (2.14-4.16) | 3.13 ± 0.15, 3.00 (1.65-4.14) |
| MCP-1 level, pg/mL | 334 ± 22, 310 (206-546) | 350 ± 63, 255 (197-460) |
| sCD40L level, pg/mL | 547 ± 95, 276 (68-1122) | 468 ± 93, 443 (188-1200) |
| CRP level, mg/mL | 0.44 ± 0.07, 0.33 (0.02-0.93) | 0.48 ± 0.07, 0.41 (0.3-1.1) |
| sVCAM level, ng/mL | 697 ± 68, 625 (260-1301) | 465 ± 27, 473 (286-691)* |
| P-selectin level, ng/mL | 96 ± 8.6, 80 (51.6-163) | 79 ± 3.6, 80 (56-119) |
| 8-iso-PGF2α pg/mg creatinine level | 257 ± 39, 188 (89-520) | 279 ± 55, 228 (81-917) |
| IMT, mm | 1.2 ± 0.06, 1.2 (0.7-1.6) | 0.82 ± 0.02, 0.8 (0.7-1)† |
| Medications | ||
| Nitrates, no. (%) | 0 (0) | 1 (5) |
| β-Blockers, no. (%) | 1 (6) | 4 (24) |
| Calcium channel blockers, no. (%) | 4 (24) | 6 (35) |
| ACE inhibitors, no. (%) | 14 (82) | 9 (53) |
| Diuretics, no. (%) | 3 (18) | 5 (29) |
| Statins, no. (%) | 3 (18) | 3 (18) |