Table 3. Donor BPI haplotypes in the... | American Society of Hematology

Table 3.

Donor BPI haplotypes in the discovery and validation cohorts and their associated risk of significant airflow decline after transplantation

	tagSNPs
Haplotype	2738	7258	9083	10214	17016	23356	33065	36045	Controls	Cases	Odds ratio (95% CI)	P values
Discovery cohort: all donors (N = 363)
1	C	G	G	A	A	T	G	G	0.224	0.175	Referent	—
2	G	A	G	A	G	C	A	A	0.119	0.169	2.16 (1.18-3.93)	.012
3	C	A	G	A	G	C	A	A	0.114	0.117	1.32 (0.71-2.45)	.379
4	C	A	G	A	G	C	G	G	0.075	0.1	1.93 (0.92-4.04)	.081
5	C	G	G	A	A	T	A	A	0.059	0.072	2.13 (0.94-4.81)	.07
6	C	G	C	A	A	C	G	G	0.04	0.04	1.87 (0.73-4.78)	.189
7	C	G	G	G	G	C	A	G	0.04	0.035	1.03 (0.37-2.89)	.959
8	G	A	G	A	G	C	G	G	0.036	0.035	1.24 (0.37-4.16)	.726
9	C	A	G	A	G	C	A	G	0.036	0.023	0.87 (0.1-3.87)	.854
10	C	G	G	A	A	C	A	G	0.037	0.014	0.5 (0.13-1.93)	.312
11	C	G	G	G	G	C	G	G	0.03	0.017	0.95 (0.14-3.7)	.938
12	C	G	C	A	A	T	G	G	0.024	0.038	2.4 (0.76-7.55)	.134
13	C	G	G	G	G	C	A	A	0.021	0.04	2.83 (1.39-10.51)	.009
14	C	G	G	A	A	C	A	A	0.015	0.023	2.42 (0.71-8.29)	.159
15	G	A	G	A	G	C	A	G	0.013	0.016	1.44 (0.22-9.48)	.705
Validation cohort: all donors
1	G	G	G	A	A	T	A	A	0.075	0.019	Referent	—
2	G	G	G	A	A	T	G	G	0.217	0.284	5.99 (1.08-33.23)	.041
3	G	A	G	A	G	C	A	A	0.129	0.085	2.68 (0.4-17.88)	.31
4	G	A	G	A	G	C	G	G	0.096	0.133	6.96 (1.24-39.06)	.028
5	C	A	G	A	G	C	A	A	0.091	0.107	6.36 (1.06-38.32)	.043
6	G	G	G	G	G	C	A	A	0.05	0.055	5.84 (0.82-41.38)	.077
7	G	A	G	A	G	C	A	G	0.05	0.033	3.28 (0.49-22.05)	.222
8	C	A	G	A	G	C	G	G	0.039	0.042	4.68 (0.55-39.98)	.158
9	G	G	C	A	A	T	G	G	0.038	0.055	8.57 (1.25-58.72)	.029
10	G	G	G	G	G	C	A	G	0.038	0.027	3.21 (0.37-27.78)	.289
11	G	G	C	A	A	C	G	G	0.035	0.06	8.0 (1.19-53.89)	.033

	tagSNPs
Haplotype	2738	7258	9083	10214	17016	23356	33065	36045	Controls	Cases	Odds ratio (95% CI)	P values
Discovery cohort: all donors (N = 363)
1	C	G	G	A	A	T	G	G	0.224	0.175	Referent	—
2	G	A	G	A	G	C	A	A	0.119	0.169	2.16 (1.18-3.93)	.012
3	C	A	G	A	G	C	A	A	0.114	0.117	1.32 (0.71-2.45)	.379
4	C	A	G	A	G	C	G	G	0.075	0.1	1.93 (0.92-4.04)	.081
5	C	G	G	A	A	T	A	A	0.059	0.072	2.13 (0.94-4.81)	.07
6	C	G	C	A	A	C	G	G	0.04	0.04	1.87 (0.73-4.78)	.189
7	C	G	G	G	G	C	A	G	0.04	0.035	1.03 (0.37-2.89)	.959
8	G	A	G	A	G	C	G	G	0.036	0.035	1.24 (0.37-4.16)	.726
9	C	A	G	A	G	C	A	G	0.036	0.023	0.87 (0.1-3.87)	.854
10	C	G	G	A	A	C	A	G	0.037	0.014	0.5 (0.13-1.93)	.312
11	C	G	G	G	G	C	G	G	0.03	0.017	0.95 (0.14-3.7)	.938
12	C	G	C	A	A	T	G	G	0.024	0.038	2.4 (0.76-7.55)	.134
13	C	G	G	G	G	C	A	A	0.021	0.04	2.83 (1.39-10.51)	.009
14	C	G	G	A	A	C	A	A	0.015	0.023	2.42 (0.71-8.29)	.159
15	G	A	G	A	G	C	A	G	0.013	0.016	1.44 (0.22-9.48)	.705
Validation cohort: all donors
1	G	G	G	A	A	T	A	A	0.075	0.019	Referent	—
2	G	G	G	A	A	T	G	G	0.217	0.284	5.99 (1.08-33.23)	.041
3	G	A	G	A	G	C	A	A	0.129	0.085	2.68 (0.4-17.88)	.31
4	G	A	G	A	G	C	G	G	0.096	0.133	6.96 (1.24-39.06)	.028
5	C	A	G	A	G	C	A	A	0.091	0.107	6.36 (1.06-38.32)	.043
6	G	G	G	G	G	C	A	A	0.05	0.055	5.84 (0.82-41.38)	.077
7	G	A	G	A	G	C	A	G	0.05	0.033	3.28 (0.49-22.05)	.222
8	C	A	G	A	G	C	G	G	0.039	0.042	4.68 (0.55-39.98)	.158
9	G	G	C	A	A	T	G	G	0.038	0.055	8.57 (1.25-58.72)	.029
10	G	G	G	G	G	C	A	G	0.038	0.027	3.21 (0.37-27.78)	.289
11	G	G	C	A	A	C	G	G	0.035	0.06	8.0 (1.19-53.89)	.033

For discovery cohort, n = 363; for validation cohort, n = 209. Haplotypes with a P ≤ 05 are shown in italics. All haplotypes were analyzed in multivariate models that included age at transplantation, pretransplantation; FEV₁, extent of GVHD, and duration of follow-up as covariates.

— indicates no P value for the group.

View Large

This Feature Is Available To Subscribers Only