Table 2. Suicide gene therapy of severe... | American Society of Hematology

Table 2.

Suicide gene therapy of severe GvHD

Cells, treatment	Average human chimerism, % (range)	Average clinical index, arbitrary units	Survival
PBLs
Saline
Day 0	29.8 (16.5-53.2)	5.2 ± 1.2	6/6
Day +7	78.5 (73.1-83.9)^*	8.5 ± 0.7†	2/6
Day +14	—	—	0/6
GCV
Day 0	35.8 (18.9-83.9)	5.4 ± 0.9	8/8
Day +7	85.8 (69.9-94.2)†	8.3 ± 0.6^*	3/8
Day +14	—	—	0/8
baCD3/CD28-TK⁺
Saline
Day 0	24.3 (10.3-34.1)	4.3 ± 1.5	4/4
Day +7	43.4 (33.1-58.3)†	7.7 ± 0.6†	3/4
Day +14	—	—	0/4
GCV
Day 0	27.8 (19.5-35.2)	4.7 ± 0.8	6/6
Day +7	1.8 (0.9-3.1)^*	6.0 ± 0.7†	5/6
Day +14	0.7 (0.4-1.7)‡	4.4 ± 1.1	5/6§

Cells, treatment	Average human chimerism, % (range)	Average clinical index, arbitrary units	Survival
PBLs
Saline
Day 0	29.8 (16.5-53.2)	5.2 ± 1.2	6/6
Day +7	78.5 (73.1-83.9)^*	8.5 ± 0.7†	2/6
Day +14	—	—	0/6
GCV
Day 0	35.8 (18.9-83.9)	5.4 ± 0.9	8/8
Day +7	85.8 (69.9-94.2)†	8.3 ± 0.6^*	3/8
Day +14	—	—	0/8
baCD3/CD28-TK⁺
Saline
Day 0	24.3 (10.3-34.1)	4.3 ± 1.5	4/4
Day +7	43.4 (33.1-58.3)†	7.7 ± 0.6†	3/4
Day +14	—	—	0/4
GCV
Day 0	27.8 (19.5-35.2)	4.7 ± 0.8	6/6
Day +7	1.8 (0.9-3.1)^*	6.0 ± 0.7†	5/6
Day +14	0.7 (0.4-1.7)‡	4.4 ± 1.1	5/6§

Values for average clinical index are ± SD.

— indicates not applicable.

P < .01 for comparison with day 0

P < .05 for comparison with day 0

P < .01 for comparison with day 0

P < .001 for comparison with mice infused with baCD3/CD28-TK⁺ lymphocytes and treated with saline