Receptor tyrosine kinases inhibited by BIBF 1000
Receptor tyrosine kinase . | IC50BIBF 1000, nM . |
|---|---|
| VEGFR1 | 40 |
| VEGFR2 | 28 |
| VEGFR3 | 142 |
| FGFR1 | 43 |
| FGFR3 | 52 |
| PDGFRα | 35 |
| EGFR | > 50 000 |
| HER-2 | > 10 000 |
| IGFR1 | > 10 000 |
| InsR | > 10 000 |
| HGFR | > 10 000 |
| CDK1 | > 10 000 |
| CDK2 | > 10 000 |
| CDK4 | > 10 000 |
Receptor tyrosine kinase . | IC50BIBF 1000, nM . |
|---|---|
| VEGFR1 | 40 |
| VEGFR2 | 28 |
| VEGFR3 | 142 |
| FGFR1 | 43 |
| FGFR3 | 52 |
| PDGFRα | 35 |
| EGFR | > 50 000 |
| HER-2 | > 10 000 |
| IGFR1 | > 10 000 |
| InsR | > 10 000 |
| HGFR | > 10 000 |
| CDK1 | > 10 000 |
| CDK2 | > 10 000 |
| CDK4 | > 10 000 |