Table 5. Heterogeneity of pv- and v- gag... | American Society of Hematology

Table 5.

Heterogeneity of pv- and v-gag and -env

			Differences in mobility on HMA			Diversity within provirus and virus, %			Diversity between pv and v, %
Patients	Sequenced gene	Subtype	Provirus	Virus	Provirus	Virus		Changes in epitopes	Diversity between pv and v, %
P12	gag	CRF01-AE	11/25	13/25	2.59	1.69	2.83	SLYNTVATL
								SLFNTIATL^*
								SLFNTVATL†
P14	gag	CRF02-AG	14/25	13/25	0.91	1.69	1.90	SLYNTVATL
								SLFNTLATL‡
P24	env	CRF03-AB	6/18	12/42	1.36	1.40	1.50	Mutations in nonimmunodominant epitopes
P25	env	B	6/36	8/44	3.8	4.57	4.68	Deletions and mutations in nonimmunodominant epitopes

			Differences in mobility on HMA			Diversity within provirus and virus, %			Diversity between pv and v, %
Patients	Sequenced gene	Subtype	Provirus	Virus	Provirus	Virus		Changes in epitopes	Diversity between pv and v, %
P12	gag	CRF01-AE	11/25	13/25	2.59	1.69	2.83	SLYNTVATL
								SLFNTIATL^*
								SLFNTVATL†
P14	gag	CRF02-AG	14/25	13/25	0.91	1.69	1.90	SLYNTVATL
								SLFNTLATL‡
P24	env	CRF03-AB	6/18	12/42	1.36	1.40	1.50	Mutations in nonimmunodominant epitopes
P25	env	B	6/36	8/44	3.8	4.57	4.68	Deletions and mutations in nonimmunodominant epitopes

PCR templates of gag (patients P12 and P14) or env (patients P24 and P25) from plasma virus or from provirus were analyzed for differences in mobility on HMA (values indicate number of clones of the provirus tested on HMA showing difference in mobility out of total number of clones) and for differences in sequence.

Underlined letters represent mutations in the epitope.

These mutations were found in 7 of 11 proviruses and 1 of 13 viruses

†

This mutation was found in 4 of 11 proviruses and 12 of 13 viruses

‡

These mutations were found in all proviruses and viruses

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