Table 1.

Effect of BiLu treatment on GVHD in tumor-bearing mice


Effector cells

BiLu treatment

No. of mice with GVHD/total no. of mice
C57BL/6   -   23/27  
C57BL/6   +   5/25  
BALB/c   -   1/32  
BALB   +   0/20  
BALB, 2 ×*  -   7/27  
BALB/c, 2 ×*
 
+
 
0/10
 

Effector cells

BiLu treatment

No. of mice with GVHD/total no. of mice
C57BL/6   -   23/27  
C57BL/6   +   5/25  
BALB/c   -   1/32  
BALB   +   0/20  
BALB, 2 ×*  -   7/27  
BALB/c, 2 ×*
 
+
 
0/10
 

F1 mice were inoculated with B16-EpCAM melanoma cells (5 × 103) after conditioning with 4 Gy TBI. One day later, 30 × 106 splenocytes derived either from C57 or BALB mice were injected intraperitoneally.

*

Two injections of BALB splenocytes were done at intervals of 4 days

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