Table 3. Transplanted human ALDH hi... | American Society of Hematology

Table 3.

Transplanted human ALDH^hiCD133⁺Lin^- cells retain primitive hematopoietic surface markers after repopulation in vivo

Transplanted cell population	CD34⁺, %	CD34⁺CD38⁺, %	CD34⁺CD38^-, %	CD34⁺CD133⁺, %
ALDH^hiCD133⁺Lin^-	30.0 ± 4.7^*	27.4 ± 4.7^*	2.6 ± 0.3†	6.8 ± 1.1‡
CD133⁺Lin^-	25.3 ± 4.0^*	22.7 ± 3.6^*	2.6 ± 0.6†	6.1 ± 1.1‡
ALDH^hiLin^-	14.0 ± 2.6^*	13.8 ± 2.2	0.2 ± 0.1	1.5 ± 0.6

Transplanted cell population	CD34⁺, %	CD34⁺CD38⁺, %	CD34⁺CD38^-, %	CD34⁺CD133⁺, %
ALDH^hiCD133⁺Lin^-	30.0 ± 4.7^*	27.4 ± 4.7^*	2.6 ± 0.3†	6.8 ± 1.1‡
CD133⁺Lin^-	25.3 ± 4.0^*	22.7 ± 3.6^*	2.6 ± 0.6†	6.1 ± 1.1‡
ALDH^hiLin^-	14.0 ± 2.6^*	13.8 ± 2.2	0.2 ± 0.1	1.5 ± 0.6

Mean expression of primitive cell surface markers after the transplantation of purified ALDH^hiCD133⁺Lin^- (n = 6) or CD133⁺Lin^- (n = 5) cells was compared with BM repopulation produced by purified ALDH^hiLin^- cells (n = 5). Populations that received transplants of ALDH^hiCD133⁺Lin^- and CD133⁺Lin^- retained cells that expressed CD34 and showed increased frequencies of CD34⁺CD38⁺ progenitors and CD34⁺CD38^- repopulating cells.

P < .05

†

P < .001

‡

P < .01

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