Sequence comparison of the putative Goodpasture epitope EB
Species/chain . | GP+/– . | Epitope EB sequence . |
|---|---|---|
| Human α1 NC1 | – | I Q I P P C P S G W S S L W I |
| Human α3 NC1 | + | T D I P P C P H G W I S W L K |
| Bovine α3 NC1 | + | T D - - - - - A - - I - - - K |
| Rattus α3 NC1 | + | T A - - - - - Q - - V - - - K |
| Mus α3 NC1 | + | T A - - - - - Q D - V - - - K |
| Gallus α3 NC1 | + | T A V - A - - G - - I - - - K |
| Xenopus α3 NC1 | + | Missing/unknown |
| Danio rerio α3 NC1 | – | I N - - Q - - V - - L - - - E |
| Drosophila α1 NC1 | – | I E V - D - - N - - E G - - I |
| C elegans α1 NC1 | – | T S V - Q - - Q - - S G M - T |
| Residue number | 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 |
Species/chain . | GP+/– . | Epitope EB sequence . |
|---|---|---|
| Human α1 NC1 | – | I Q I P P C P S G W S S L W I |
| Human α3 NC1 | + | T D I P P C P H G W I S W L K |
| Bovine α3 NC1 | + | T D - - - - - A - - I - - - K |
| Rattus α3 NC1 | + | T A - - - - - Q - - V - - - K |
| Mus α3 NC1 | + | T A - - - - - Q D - V - - - K |
| Gallus α3 NC1 | + | T A V - A - - G - - I - - - K |
| Xenopus α3 NC1 | + | Missing/unknown |
| Danio rerio α3 NC1 | – | I N - - Q - - V - - L - - - E |
| Drosophila α1 NC1 | – | I E V - D - - N - - E G - - I |
| C elegans α1 NC1 | – | T S V - Q - - Q - - S G M - T |
| Residue number | 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 |
Dashes in sequences indicate conserved and therefore nonreactive residues identical to those found in both human α1 and human α3 NC1 domains. Residue numbers are based on human α3(IV)NC1 residue positions.