Table 4.

Tissues and morphologic features graded


Tissue

Features graded
Brain   Pyknotic Purkinje cells; iron pigment  
Eyes   Retinal degeneration; iron pigment; infarcts  
Lungs   Infarcts; thickness of intima and media of pulmonary arteries; mononuclear infiltrates; iron pigment; hemorrhages; vascular congestion; dilated capillaries  
Kidneys   Glomerular diameter; cysts and infarcts; thickness of vascular intima and media on 10 × near renal sinus; iron pigment; mononuclear infiltrates  
Liver   Calcification; infarcts; iron pigment; mononuclear infiltrates; pericentral venous pallor; steatosis  
Spleen   Diameter of spleen (mm); increased white pulp (hematopoietic cells); luminal diameter (ectasia) of blood vessel in the white pulp; iron pigment; infarcts  
Heart   Infarcts (recent/remote); vascular wall thickness; iron pigment; thickness of left and right ventricular free walls (mm)  
Pancreas   Greatest islet diameter  
Bone marrow   Cellularity, erythroid hyperplasia, iron pigment  
Intravascular erythrocytes   Percentage of cells demonstrating sickle morphology  
Carotid arteries
 
Abnormalities of the endothelium, intima, media, and adventitia
 

Tissue

Features graded
Brain   Pyknotic Purkinje cells; iron pigment  
Eyes   Retinal degeneration; iron pigment; infarcts  
Lungs   Infarcts; thickness of intima and media of pulmonary arteries; mononuclear infiltrates; iron pigment; hemorrhages; vascular congestion; dilated capillaries  
Kidneys   Glomerular diameter; cysts and infarcts; thickness of vascular intima and media on 10 × near renal sinus; iron pigment; mononuclear infiltrates  
Liver   Calcification; infarcts; iron pigment; mononuclear infiltrates; pericentral venous pallor; steatosis  
Spleen   Diameter of spleen (mm); increased white pulp (hematopoietic cells); luminal diameter (ectasia) of blood vessel in the white pulp; iron pigment; infarcts  
Heart   Infarcts (recent/remote); vascular wall thickness; iron pigment; thickness of left and right ventricular free walls (mm)  
Pancreas   Greatest islet diameter  
Bone marrow   Cellularity, erythroid hyperplasia, iron pigment  
Intravascular erythrocytes   Percentage of cells demonstrating sickle morphology  
Carotid arteries
 
Abnormalities of the endothelium, intima, media, and adventitia
 

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