Variables entered in the multivariate analysis
Main effect: type of graft |
| HLA-identical sibling BM transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| HLA-identical sibling PBSC transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| Matched unrelated BM transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| Patient-related variables |
| Age: as a continuous variable |
| Sex: female,* male |
| Karnofsky performance score at transplantation: 80%-100%,* < 80% |
| Disease-related variables |
| Disease type: AML* vs CML |
| Disease stage at diagnosis.† early* vs intermediate vs advanced |
| Transplantation-related variables |
| Conditioning regimen: TBI vs no TBI* |
| Donor CMV serostatus: positive* vs others |
| Recipient CMV serostatus: positive* vs others |
| Donor-recipient sex match: F-M* vs other |
| Year of transplantation: 1995-1996,* 1997-1998, 1999-2000 |
| BM indicates bone marrow; G-CSF, granulocyte colony-stimulating factor; PBSC, peripheral blood stem cell; AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; TBI, total body irradiation; CMV, cytomegalovirus; F, female; and M, male |
Main effect: type of graft |
| HLA-identical sibling BM transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| HLA-identical sibling PBSC transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| Matched unrelated BM transplant with G-CSF in the first 7 days after transplantation versus without G-CSF* |
| Patient-related variables |
| Age: as a continuous variable |
| Sex: female,* male |
| Karnofsky performance score at transplantation: 80%-100%,* < 80% |
| Disease-related variables |
| Disease type: AML* vs CML |
| Disease stage at diagnosis.† early* vs intermediate vs advanced |
| Transplantation-related variables |
| Conditioning regimen: TBI vs no TBI* |
| Donor CMV serostatus: positive* vs others |
| Recipient CMV serostatus: positive* vs others |
| Donor-recipient sex match: F-M* vs other |
| Year of transplantation: 1995-1996,* 1997-1998, 1999-2000 |
| BM indicates bone marrow; G-CSF, granulocyte colony-stimulating factor; PBSC, peripheral blood stem cell; AML, acute myelogenous leukemia; CML, chronic myelogenous leukemia; TBI, total body irradiation; CMV, cytomegalovirus; F, female; and M, male |
Reference group
Disease stage classified as the following: early leukemia = first complete remission or first chronic phase; intermediate leukemia = greater than or equal to second complete remission; greater than or equal to second chronic phase or accelerated phase; and advanced leukemia = patients never in remission, in any relapse or blast phase