Laboratory and clinical features at diagnosis of idiopathic myelofibrosis analyzed by presence or absence of the JAK2 V617F mutation
. | JAK2 V617F . | JAK2 wild-type . | P . |
|---|---|---|---|
| Total, no. | 83 | 69 | |
| Percentage (95% CI) | 54.6 (50.7-58.5) | 45.4 (41.5-49.3) | |
| Demographics | |||
| Male, no. (%) | 44 (53) | 42 (61) | .3 |
| Female, no. (%) | 39 (47) | 27 (39) | |
| Median age, y (10th-90th centile) | 64 (48-77) | 62 (43-77) | .3 |
| Laboratory and clinical features at diagnosis | |||
| LDH, U/L | .9 | ||
| Mean ± SD | 546 ± 374 | 501 ± 358 | |
| Median (10th-90th centile) | 440 (182-939) | 451 (214-764) | |
| CD34, × 106/L | .9 | ||
| Mean ± SD | 568 ± 724 | 620 ± 840 | |
| Median (10th-90th centile) | 292 (67-1332) | 222 (22-1345) | |
| Blast cell count, × 109/L | .5 | ||
| Mean ± SD | 0.25 ± 0.85 | 0.29 ± 0.71 | |
| Median (10th-90th centile) | 0.02 (0-0.56) | 0.06 (0-0.67) | |
| Hemoglobin level, g/L | .1 | ||
| Mean ± SD | 110 ± 24 | 104 ± 22 | |
| Median (10th-90th centile) | 109 (73-139) | 100 (81-132) | |
| White cell count, × 109/L | .02 | ||
| Mean ± SD | 15.3 ± 15.4 | 10.1 ± 7.9 | |
| Median (10th-90th centile) | 10.0 (4.0-32.9) | 7.2 (2.5-21.1) | |
| Neutrophil count, × 109/L | .02 | ||
| Mean ± SD | 13.1 ± 15.7 | 8.1 ± 12.1 | |
| Median (10th-90th centile) | 7.7 (2.9-23.7) | 4.7 (1.8-16.1) | |
| Platelet count, × 109/L | .3 | ||
| Mean ± SD | 312 ± 252 | 254 ± 203 | |
| Median (10th-90th centile) | 227 (51-723) | 232 (48-494) | |
| Spleen size, cm | .7 | ||
| Mean ± SD | 6.7 ± 5.2 | 7.4 ± 6.0 | |
| Median (10th-90th centile) | 7.0 (0-14.0) | 5.0 (0-15.0) | |
| Cytogenetics, no. | .8 | ||
| Normal | 18 | 22 | |
| Abnormal | 16 | 15 | |
| Lille score, no. | .06 | ||
| 0 | 36 | 17 | |
| 1 | 23 | 28 | |
| 2 | 6 | 5 | |
| Transfusion required during follow-up, no. | .03 | ||
| None | 47 | 25 | |
| Intermittent or regular | 31 | 35 |
. | JAK2 V617F . | JAK2 wild-type . | P . |
|---|---|---|---|
| Total, no. | 83 | 69 | |
| Percentage (95% CI) | 54.6 (50.7-58.5) | 45.4 (41.5-49.3) | |
| Demographics | |||
| Male, no. (%) | 44 (53) | 42 (61) | .3 |
| Female, no. (%) | 39 (47) | 27 (39) | |
| Median age, y (10th-90th centile) | 64 (48-77) | 62 (43-77) | .3 |
| Laboratory and clinical features at diagnosis | |||
| LDH, U/L | .9 | ||
| Mean ± SD | 546 ± 374 | 501 ± 358 | |
| Median (10th-90th centile) | 440 (182-939) | 451 (214-764) | |
| CD34, × 106/L | .9 | ||
| Mean ± SD | 568 ± 724 | 620 ± 840 | |
| Median (10th-90th centile) | 292 (67-1332) | 222 (22-1345) | |
| Blast cell count, × 109/L | .5 | ||
| Mean ± SD | 0.25 ± 0.85 | 0.29 ± 0.71 | |
| Median (10th-90th centile) | 0.02 (0-0.56) | 0.06 (0-0.67) | |
| Hemoglobin level, g/L | .1 | ||
| Mean ± SD | 110 ± 24 | 104 ± 22 | |
| Median (10th-90th centile) | 109 (73-139) | 100 (81-132) | |
| White cell count, × 109/L | .02 | ||
| Mean ± SD | 15.3 ± 15.4 | 10.1 ± 7.9 | |
| Median (10th-90th centile) | 10.0 (4.0-32.9) | 7.2 (2.5-21.1) | |
| Neutrophil count, × 109/L | .02 | ||
| Mean ± SD | 13.1 ± 15.7 | 8.1 ± 12.1 | |
| Median (10th-90th centile) | 7.7 (2.9-23.7) | 4.7 (1.8-16.1) | |
| Platelet count, × 109/L | .3 | ||
| Mean ± SD | 312 ± 252 | 254 ± 203 | |
| Median (10th-90th centile) | 227 (51-723) | 232 (48-494) | |
| Spleen size, cm | .7 | ||
| Mean ± SD | 6.7 ± 5.2 | 7.4 ± 6.0 | |
| Median (10th-90th centile) | 7.0 (0-14.0) | 5.0 (0-15.0) | |
| Cytogenetics, no. | .8 | ||
| Normal | 18 | 22 | |
| Abnormal | 16 | 15 | |
| Lille score, no. | .06 | ||
| 0 | 36 | 17 | |
| 1 | 23 | 28 | |
| 2 | 6 | 5 | |
| Transfusion required during follow-up, no. | .03 | ||
| None | 47 | 25 | |
| Intermittent or regular | 31 | 35 |