Patient characteristics and univariate analysis
. | . | OS . | . | Current LFS . | . | TRM . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Factor . | No. patients . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | |||
| Age | .38 | .38 | .29 | |||||||
| Less than 36 y | 38 | 25 (65 ± 7) | 23 (59 ± 8) | 10 (26 ± 7) | ||||||
| At least 36 y | 42 | 31 (73 ± 7) | 28 (66 ± 7) | 7 (17 ± 6) | ||||||
| Sex | .40 | .29 | .76 | |||||||
| Male | 53 | 35 (65 ± 7) | 31 (57 ± 7) | 12 (24 ± 5) | ||||||
| Female | 27 | 21 (78 ± 8) | 20 (74 ± 9) | 5 (19 ± 7) | ||||||
| Disease phase | < .001 | < .001 | .007 | |||||||
| Chronic | 54 | 46 (85 ± 5) | 42 (76 ± 6) | 7 (13 ± 5) | ||||||
| Advanced | 26 | 10 (36 ± 10) | 9 (34 ± 9) | 10 (43 ± 11) | ||||||
| Donor-patient sex match | .88 | .82 | .82 | |||||||
| F to M | 13 | 9 (69 ± 13) | 9 (69 ± 13) | 3 (24 ± 9) | ||||||
| Others | 67 | 47 (69 ± 6) | 42 (61 ± 6) | 14 (22 ± 8) | ||||||
| Transplantation type | .16 | .54 | .08 | |||||||
| BMT | 25 | 15 (60 ± 10) | 15 (60 ± 10) | 8 (33 ± 10) | ||||||
| PBSCT | 55 | 41 (74 ± 6) | 36 (63 ± 7) | 9 (16 ± 5) | ||||||
| CSA dose | .29 | .27 | .48 | |||||||
| SD | 41 | 26 (63 ± 8) | 26 (63 ± 8) | 10 (25 ± 7) | ||||||
| LD | 5 | 5 (100) | 5 (100) | 0 (0) | ||||||
| N | 34 | 25 (74 ± 8) | 20 (54 ± 9) | 7 (21 ± 6) | ||||||
| CD34 dose | .005 | .01 | .05 | |||||||
| Less than 4.5 × 106/kg | 40 | 22 (55 ± 8) | 20 (50 ± 8) | 12 (31 ± 8) | ||||||
| More than 4.5 × 106/kg | 40 | 34 (85 ± 6) | 31 (76 ± 7) | 5 (12 ± 5) | ||||||
| CD3 dose | .43 | .29 | .38 | |||||||
| 1 × 105/kg | 16 | 11 (69 ± 12) | 11 (69 ± 12) | 2 (13 ± 8) | ||||||
| 0.2 × 106/kg | 17 | 12 (68 ± 12) | 9 (55 ± 13) | 3 (19 ± 9) | ||||||
| 2 × 106/kg | 25 | 15 (60 ± 10) | 15 (60 ± 10) | 8 (33 ± 9) | ||||||
| 0.5 × 106/kg | 22 | 18 (81 ± 8) | 16 (73 ± 9) | 4 (18 ± 8) | ||||||
| LC30 | < .001 | < .001 | .01 | |||||||
| Less than 0.30 × 109/L | 40 | 19 (46 ± 8) | 17 (41 ± 8) | 14 (33 ± 3) | ||||||
| More than 0.30 × 109/L | 40 | 37 (93 ± 4) | 34 (85 ± 6) | 3 (8.5 ± 4.7) | ||||||
. | . | OS . | . | Current LFS . | . | TRM . | . | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Factor . | No. patients . | No. (%) . | P . | No. (%) . | P . | No. (%) . | P . | |||
| Age | .38 | .38 | .29 | |||||||
| Less than 36 y | 38 | 25 (65 ± 7) | 23 (59 ± 8) | 10 (26 ± 7) | ||||||
| At least 36 y | 42 | 31 (73 ± 7) | 28 (66 ± 7) | 7 (17 ± 6) | ||||||
| Sex | .40 | .29 | .76 | |||||||
| Male | 53 | 35 (65 ± 7) | 31 (57 ± 7) | 12 (24 ± 5) | ||||||
| Female | 27 | 21 (78 ± 8) | 20 (74 ± 9) | 5 (19 ± 7) | ||||||
| Disease phase | < .001 | < .001 | .007 | |||||||
| Chronic | 54 | 46 (85 ± 5) | 42 (76 ± 6) | 7 (13 ± 5) | ||||||
| Advanced | 26 | 10 (36 ± 10) | 9 (34 ± 9) | 10 (43 ± 11) | ||||||
| Donor-patient sex match | .88 | .82 | .82 | |||||||
| F to M | 13 | 9 (69 ± 13) | 9 (69 ± 13) | 3 (24 ± 9) | ||||||
| Others | 67 | 47 (69 ± 6) | 42 (61 ± 6) | 14 (22 ± 8) | ||||||
| Transplantation type | .16 | .54 | .08 | |||||||
| BMT | 25 | 15 (60 ± 10) | 15 (60 ± 10) | 8 (33 ± 10) | ||||||
| PBSCT | 55 | 41 (74 ± 6) | 36 (63 ± 7) | 9 (16 ± 5) | ||||||
| CSA dose | .29 | .27 | .48 | |||||||
| SD | 41 | 26 (63 ± 8) | 26 (63 ± 8) | 10 (25 ± 7) | ||||||
| LD | 5 | 5 (100) | 5 (100) | 0 (0) | ||||||
| N | 34 | 25 (74 ± 8) | 20 (54 ± 9) | 7 (21 ± 6) | ||||||
| CD34 dose | .005 | .01 | .05 | |||||||
| Less than 4.5 × 106/kg | 40 | 22 (55 ± 8) | 20 (50 ± 8) | 12 (31 ± 8) | ||||||
| More than 4.5 × 106/kg | 40 | 34 (85 ± 6) | 31 (76 ± 7) | 5 (12 ± 5) | ||||||
| CD3 dose | .43 | .29 | .38 | |||||||
| 1 × 105/kg | 16 | 11 (69 ± 12) | 11 (69 ± 12) | 2 (13 ± 8) | ||||||
| 0.2 × 106/kg | 17 | 12 (68 ± 12) | 9 (55 ± 13) | 3 (19 ± 9) | ||||||
| 2 × 106/kg | 25 | 15 (60 ± 10) | 15 (60 ± 10) | 8 (33 ± 9) | ||||||
| 0.5 × 106/kg | 22 | 18 (81 ± 8) | 16 (73 ± 9) | 4 (18 ± 8) | ||||||
| LC30 | < .001 | < .001 | .01 | |||||||
| Less than 0.30 × 109/L | 40 | 19 (46 ± 8) | 17 (41 ± 8) | 14 (33 ± 3) | ||||||
| More than 0.30 × 109/L | 40 | 37 (93 ± 4) | 34 (85 ± 6) | 3 (8.5 ± 4.7) | ||||||
Median age of patients was 36 years; range was 12 to 58 years. Median CD34 dose was 4.5 × 106/kg. Median LC30 was 0.297 × 109/L.