Table 3.

Top 105 probe sets selected for genes overexpressed in DS AMkL compared with non-DS AMkL

Gene name
Fold change
Gene symbol
GenBank no.
Chromosomal location
Description
219870_at   0.5  ATF71P2 NM_024997  16p13.2   Activating transcription factor 7 interacting protein 2  
203377_s_at   0.498  CDC40 NM_015891  6q22.1   Cell division cycle 40 homolog (yeast)  
217793_at   0.494  RAB11B  AL575337   19p13.3   RAB11B, member RAS oncogene family  
206875_s_at   0.491  SLK NM_014720  10q25.1   SNF1 sucrose nonfermenting like kinase (yeast)  
203910_at   0.491  PARG1 NM_004815  1p22.1   PTPL1-associated RhoGAP1  
221832_s_at   0.491  AOF2  AV741657   1p36.11   Amine oxidase (flavin containing) domain 2  
210718_s_at   0.49  LOC51326  AF119889   17q21.32   ARF protein  
218712_at   0.489  FLJ20508 NM_017850  1p34.2   Hypothetical protein FLJ20508 
214801_at   0.485   —   W88821   —   CDNA FLJ11392 fis, clone HEMBA1000575  
212246_at   0.482  MCFD2  BE880828   2p21   Multiple coagulation factor deficiency 2  
202008_s_at   0.48  NID NM_002508  1q43   Nidogen (enactin)  
202421_at   0.476  IGSF3  AB007935   1p13   Immunoglobulin superfamily, member 3  
222329_x_at   0.463   —   AW974816   —   Transcribed sequence with weak similarity to protein sp:P39188 (Homo sapiens) ALU1_HUMAN Alu subfamily J sequence contamination warning entry  
202557_at   0.46  STCH  AI718418   21q11.1   Stress 70 protein chaperone, microsome-associated, 60 kDa  
209045_at   0.459  XPNPEP1  AF195530   10q25.3   X-prolyl aminopeptidase (aminopeptidase P) 1, soluble  
218344_s_at   0.457  FLJ10876 NM_018254  1q32.3   Hypothetical protein FLJ10876 
202468_s_at   0.451  CTNNAL1 NM_003798  9q31.2   Catenin (cadherin-associated protein), α-like 1  
203015_s_at   0.451  SSX2IP  AW136988   —   Synovial sarcoma, X breakpoint 2 interacting protein  
203224_at   0.447  FLJ11149  BF340123   9q21.31   Riboflavin kinase  
203225_s_at   0.443  FLJ11149 NM_018339  9q21.31   Riboflavin kinase  
202932_at   0.442  YES1 NM_005433  18p11.31–p11.21   v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1  
214205_x_at   0.44  TXNL2  AK022131   6p25.3   Thioredoxin-like 2  
204417_at   0.439  GALC NM_000153  14q31   Galactosylceramidase (Krabbe disease)  
210818_s_at   0.437  BACH1  AF026199   21q22.11   BTB and CNC homology 1, basic leucine zipper transcription factor 1  
207332_s_at   0.433  TFRC NM_003234  3q26.2-qter   Transferrin receptor (p90, CD71)  
202949_s_at   0.432  FHL2 NM_001450  2q12-q14   Four and a half LIM domains 2  
221580_s_at   0.425  MGC5306  BC001972   11q21   Hypothetical protein MGC5306  
207386_at   0.42  CYP7B1 NM_004820  8q21.3   Cytochrome P450, family 7, subfamily B, polypeptide 1  
207845_s_at   0.42  APC10 NM_014885  4q31   Anaphase-promoting complex subunit 10  
212884_x_at   0.414  APOE  AI358867   19q13.2   Apolipoprotein E  
212978_at   0.413  TA-LRRP  AU146004   1p22.2   T-cell activation leucine repeat-rich protein  
211810_s_at   0.405  GALC  D25284   14q31   Galactosylceramidase (Krabbe disease)  
202506_at   0.405  SSFA2 NM_006751  2q32.1   Sperm-specific antigen 2  
206693_at   0.403  IL7 NM_000880  8q12-q13   Interleukin-7  
203640_at   0.401   —   BE328496   13q32.2   hs98f09.x1 NCI_CGAP_Kid13 Homo sapiens cDNA clone IMAGE:3145289 3′, mRNA sequence  
208398_s_at   0.392  TBPL1 NM_004865  6q22.1–q22.3   TBP-like 1  
214252_s_at   0.388   —   AV700514   13q21.1–q32   AV700514 GKC Homo sapiens cDNA clone GKCDQC04 3′, mRNA sequence  
204624_at   0.387  ATP7B NM_000053  13q14.2–q21   ATPase, Cu++ transporting, β polypeptide (Wilson disease)  
213757_at   0.386  EIF5A  AA393940   17p13-p12   Eukaryotic translation initiation factor 5A  
203789_s_at   0.382  SEMA3C NM_006379  7q21-q31   Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C  
209267_s_at   0.373  SLC39A8  AB040120   4q22-q24   Solute carrier family 39 (zinc transporter), member 8  
216063_at   0.369  HBBP1  N55205   —   Transcribed sequence with moderate similarity to protein sp:P02096 (Homo sapiens) HBG_HUMAN hemoglobin γ-A and γ-G chains  
208691_at   0.367  TFRC  BC001188   3q26.2-qter   Transferrin receptor (p90, CD71)  
212990_at   0.366  SYNJ1  AB020717   21q22.2   Synaptojanin 1  
213358_at   0.365  KIAA0802  AB018345   18p11.22   KIAA0802 protein  
202558_s_at   0.361  STCH NM_006948  21q11.1   Stress 70 protein chaperone, microsome-associated, 60 kDa  
203019_x_at   0.36  SSX2IP NM_014021  —   Synovial sarcoma, X breakpoint 2 interacting protein  
205667_at   0.358  WRN NM_000553  8p12-p11.2   Werner syndrome  
219177_at   0.355  BRIX NM_018321  5p13.3   BRIX  
209676_at   0.354  TFPI  J03225   2q31-q32.1   Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  
212558_at   0.351  GDAP1L1  BF508662   20q12   Ganglioside-induced differentiation-associated protein 1-like 1  
203017_s_at   0.346  SSX21P  R52678   —   Synovial sarcoma, X breakpoint 2 interacting protein  
204976_s_at   0.338  AMMECR1  AK023637   Xq22.3   Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis chromosomal region, gene 1  
216398_at   0.338  GYPE  U05255   4q31.1   Glycophorin E  
219795_at   0.334  SLC6A14 NM_007231  Xq23-q24   Solute carrier family 6 (neurotransmitter transporter), member 14  
203544_s_at   0.329  STAM NM_003473  10p14-p13   Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1  
210664_s_at   0.318  TFPI  AF021834   2q31-q32.1   Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  
202479_s_at   0.316  TRB2  BC002637   2p25.1   Tribbles homolog 2  
202481_at   0.31  DHRS3 NM_004753  1p36.1   Dehydrogenase/reductase (SDR family) member 3  
217388_s_at
 		 0.31
 		KYNU
 		 D55639
 		 2q22.3
 		 Kynureninase (L-kynurenine hydrolase)
 
Gene name
Fold change
Gene symbol
GenBank no.
Chromosomal location
Description
219870_at   0.5  ATF71P2 NM_024997  16p13.2   Activating transcription factor 7 interacting protein 2  
203377_s_at   0.498  CDC40 NM_015891  6q22.1   Cell division cycle 40 homolog (yeast)  
217793_at   0.494  RAB11B  AL575337   19p13.3   RAB11B, member RAS oncogene family  
206875_s_at   0.491  SLK NM_014720  10q25.1   SNF1 sucrose nonfermenting like kinase (yeast)  
203910_at   0.491  PARG1 NM_004815  1p22.1   PTPL1-associated RhoGAP1  
221832_s_at   0.491  AOF2  AV741657   1p36.11   Amine oxidase (flavin containing) domain 2  
210718_s_at   0.49  LOC51326  AF119889   17q21.32   ARF protein  
218712_at   0.489  FLJ20508 NM_017850  1p34.2   Hypothetical protein FLJ20508 
214801_at   0.485   —   W88821   —   CDNA FLJ11392 fis, clone HEMBA1000575  
212246_at   0.482  MCFD2  BE880828   2p21   Multiple coagulation factor deficiency 2  
202008_s_at   0.48  NID NM_002508  1q43   Nidogen (enactin)  
202421_at   0.476  IGSF3  AB007935   1p13   Immunoglobulin superfamily, member 3  
222329_x_at   0.463   —   AW974816   —   Transcribed sequence with weak similarity to protein sp:P39188 (Homo sapiens) ALU1_HUMAN Alu subfamily J sequence contamination warning entry  
202557_at   0.46  STCH  AI718418   21q11.1   Stress 70 protein chaperone, microsome-associated, 60 kDa  
209045_at   0.459  XPNPEP1  AF195530   10q25.3   X-prolyl aminopeptidase (aminopeptidase P) 1, soluble  
218344_s_at   0.457  FLJ10876 NM_018254  1q32.3   Hypothetical protein FLJ10876 
202468_s_at   0.451  CTNNAL1 NM_003798  9q31.2   Catenin (cadherin-associated protein), α-like 1  
203015_s_at   0.451  SSX2IP  AW136988   —   Synovial sarcoma, X breakpoint 2 interacting protein  
203224_at   0.447  FLJ11149  BF340123   9q21.31   Riboflavin kinase  
203225_s_at   0.443  FLJ11149 NM_018339  9q21.31   Riboflavin kinase  
202932_at   0.442  YES1 NM_005433  18p11.31–p11.21   v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1  
214205_x_at   0.44  TXNL2  AK022131   6p25.3   Thioredoxin-like 2  
204417_at   0.439  GALC NM_000153  14q31   Galactosylceramidase (Krabbe disease)  
210818_s_at   0.437  BACH1  AF026199   21q22.11   BTB and CNC homology 1, basic leucine zipper transcription factor 1  
207332_s_at   0.433  TFRC NM_003234  3q26.2-qter   Transferrin receptor (p90, CD71)  
202949_s_at   0.432  FHL2 NM_001450  2q12-q14   Four and a half LIM domains 2  
221580_s_at   0.425  MGC5306  BC001972   11q21   Hypothetical protein MGC5306  
207386_at   0.42  CYP7B1 NM_004820  8q21.3   Cytochrome P450, family 7, subfamily B, polypeptide 1  
207845_s_at   0.42  APC10 NM_014885  4q31   Anaphase-promoting complex subunit 10  
212884_x_at   0.414  APOE  AI358867   19q13.2   Apolipoprotein E  
212978_at   0.413  TA-LRRP  AU146004   1p22.2   T-cell activation leucine repeat-rich protein  
211810_s_at   0.405  GALC  D25284   14q31   Galactosylceramidase (Krabbe disease)  
202506_at   0.405  SSFA2 NM_006751  2q32.1   Sperm-specific antigen 2  
206693_at   0.403  IL7 NM_000880  8q12-q13   Interleukin-7  
203640_at   0.401   —   BE328496   13q32.2   hs98f09.x1 NCI_CGAP_Kid13 Homo sapiens cDNA clone IMAGE:3145289 3′, mRNA sequence  
208398_s_at   0.392  TBPL1 NM_004865  6q22.1–q22.3   TBP-like 1  
214252_s_at   0.388   —   AV700514   13q21.1–q32   AV700514 GKC Homo sapiens cDNA clone GKCDQC04 3′, mRNA sequence  
204624_at   0.387  ATP7B NM_000053  13q14.2–q21   ATPase, Cu++ transporting, β polypeptide (Wilson disease)  
213757_at   0.386  EIF5A  AA393940   17p13-p12   Eukaryotic translation initiation factor 5A  
203789_s_at   0.382  SEMA3C NM_006379  7q21-q31   Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C  
209267_s_at   0.373  SLC39A8  AB040120   4q22-q24   Solute carrier family 39 (zinc transporter), member 8  
216063_at   0.369  HBBP1  N55205   —   Transcribed sequence with moderate similarity to protein sp:P02096 (Homo sapiens) HBG_HUMAN hemoglobin γ-A and γ-G chains  
208691_at   0.367  TFRC  BC001188   3q26.2-qter   Transferrin receptor (p90, CD71)  
212990_at   0.366  SYNJ1  AB020717   21q22.2   Synaptojanin 1  
213358_at   0.365  KIAA0802  AB018345   18p11.22   KIAA0802 protein  
202558_s_at   0.361  STCH NM_006948  21q11.1   Stress 70 protein chaperone, microsome-associated, 60 kDa  
203019_x_at   0.36  SSX2IP NM_014021  —   Synovial sarcoma, X breakpoint 2 interacting protein  
205667_at   0.358  WRN NM_000553  8p12-p11.2   Werner syndrome  
219177_at   0.355  BRIX NM_018321  5p13.3   BRIX  
209676_at   0.354  TFPI  J03225   2q31-q32.1   Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  
212558_at   0.351  GDAP1L1  BF508662   20q12   Ganglioside-induced differentiation-associated protein 1-like 1  
203017_s_at   0.346  SSX21P  R52678   —   Synovial sarcoma, X breakpoint 2 interacting protein  
204976_s_at   0.338  AMMECR1  AK023637   Xq22.3   Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis chromosomal region, gene 1  
216398_at   0.338  GYPE  U05255   4q31.1   Glycophorin E  
219795_at   0.334  SLC6A14 NM_007231  Xq23-q24   Solute carrier family 6 (neurotransmitter transporter), member 14  
203544_s_at   0.329  STAM NM_003473  10p14-p13   Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1  
210664_s_at   0.318  TFPI  AF021834   2q31-q32.1   Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)  
202479_s_at   0.316  TRB2  BC002637   2p25.1   Tribbles homolog 2  
202481_at   0.31  DHRS3 NM_004753  1p36.1   Dehydrogenase/reductase (SDR family) member 3  
217388_s_at
 		 0.31
 		KYNU
 		 D55639
 		 2q22.3
 		 Kynureninase (L-kynurenine hydrolase)
 
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