Triplet mismatch subgroups and CCIs
. | CCIs when HIMMs ≤ 3 . | . | CCIs when HIMMs > 3 . | . | p2 value ≤3 vs > 3 . | CCIs when total MM ≤ 9 . | . | CCIs when total MM > 9 . | . | p2 value ≤ 9 vs > 9 . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | No. . | Median . | No. . | Median . | . | No. . | Median . | No. . | Median . | . | ||||
| All transfusions | 184 | 14.0 (10-19) | 339 | 11.2 (6-16) | < .001 | 216 | 13.5 (10-18) | 307 | 11.2 (6-16) | < .001 | ||||
| CREG-compatible transfusions | 112 | 14.1 (10-20) | 58 | 8.5 (4-14) | < .001 | 120 | 13.2 (9-20) | 50 | 10.6 (4-15) | < .001 | ||||
| CREG-incompatible transfusions | 72 | 13.8 (10-17) | 281 | 11.7 (6-16) | .010 | 96 | 13.6 (10-17) | 257 | 11.2 (6-17) | .029 | ||||
. | CCIs when HIMMs ≤ 3 . | . | CCIs when HIMMs > 3 . | . | p2 value ≤3 vs > 3 . | CCIs when total MM ≤ 9 . | . | CCIs when total MM > 9 . | . | p2 value ≤ 9 vs > 9 . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
. | No. . | Median . | No. . | Median . | . | No. . | Median . | No. . | Median . | . | ||||
| All transfusions | 184 | 14.0 (10-19) | 339 | 11.2 (6-16) | < .001 | 216 | 13.5 (10-18) | 307 | 11.2 (6-16) | < .001 | ||||
| CREG-compatible transfusions | 112 | 14.1 (10-20) | 58 | 8.5 (4-14) | < .001 | 120 | 13.2 (9-20) | 50 | 10.6 (4-15) | < .001 | ||||
| CREG-incompatible transfusions | 72 | 13.8 (10-17) | 281 | 11.7 (6-16) | .010 | 96 | 13.6 (10-17) | 257 | 11.2 (6-17) | .029 | ||||
HLAMatchmaker carried out HLA-A and -B compatibility determinations at triplet level and identified the number of highly immunogenic and total triplet mismatches for each donor-patient combination. Transfusions were sorted into subgroups based on the number of mismatches (≤ 3 and > 3 HIMMs; ≤ 9 and > 9 TMMs). The median CCIs for each group was determined, and comparisons between groups were done using the Student t test. The median number of HIMMs and TMMs are presented with the first and third quartile values (in parentheses). The 2 cohorts were compared using unpaired, 2-tailed Student t test.