Odds ratios and 95% confidence intervals for the association between common IL10 haplotypes in distal and proximal promoter region and all non-Hodgkin lymphoma (NHL), and B-cell, T-cell, diffuse large B-cell lymphoma, and follicular lymphoma among non-Hispanic whites
. | . | All NHL . | . | . | B-cell lymphoma . | . | . | T-cell lymphoma . | . | . | Diffuse large B-cell lymphoma . | . | . | Follicular lymphoma . | . | . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype* . | Controls, %‡ . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | ||||||||||
| T-A-C-C | 32.4 | 27.3 | 1.0 | — | 25.8 | 1.0 | — | 34.8 | 1.0 | — | 24.3 | 1.0 | — | 24.1 | 1.0 | — | ||||||||||
| A-G-C-C | 33.0 | 38.8 | 1.44 (1.15-1.80) | .002 | 39.3 | 1.54 (1.21-1.96) | < .001 | 36.8 | 1.04 (0.56-1.92) | .90 | 40.7 | 1.67 (1.19-2.34) | .003 | 39.4 | 1.70 (1.15-2.50) | .007 | ||||||||||
| T-A-T-A | 22.4 | 23.5 | 1.28 (1.00-1.64) | .05 | 24.0 | 1.37 (1.05-1.79) | .02 | 19.6 | 0.86 (0.43-1.73) | .68 | 25.0 | 1.54 (1.06-2.23) | .023 | 27.4 | 1.73 (1.14-2.63) | .011 | ||||||||||
| T-G-C-C | 10.4 | 8.8 | 1.01 (0.73-1.40) | .95 | 9.1 | 1.10 (0.78-1.57) | .58 | 8.8 | 0.81 (0.32-2.00) | .64 | 9.7 | 1.25 (0.77-2.01) | .37 | 6.2 | 0.83 (0.44-1.56) | .57 | ||||||||||
| Global test† | — | — | — | .029 | — | — | .01 | — | — | .97 | — | — | .043 | — | — | .017 | ||||||||||
. | . | All NHL . | . | . | B-cell lymphoma . | . | . | T-cell lymphoma . | . | . | Diffuse large B-cell lymphoma . | . | . | Follicular lymphoma . | . | . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Haplotype* . | Controls, %‡ . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | %‡ . | Odds ratio†(95% CI) . | P . | ||||||||||
| T-A-C-C | 32.4 | 27.3 | 1.0 | — | 25.8 | 1.0 | — | 34.8 | 1.0 | — | 24.3 | 1.0 | — | 24.1 | 1.0 | — | ||||||||||
| A-G-C-C | 33.0 | 38.8 | 1.44 (1.15-1.80) | .002 | 39.3 | 1.54 (1.21-1.96) | < .001 | 36.8 | 1.04 (0.56-1.92) | .90 | 40.7 | 1.67 (1.19-2.34) | .003 | 39.4 | 1.70 (1.15-2.50) | .007 | ||||||||||
| T-A-T-A | 22.4 | 23.5 | 1.28 (1.00-1.64) | .05 | 24.0 | 1.37 (1.05-1.79) | .02 | 19.6 | 0.86 (0.43-1.73) | .68 | 25.0 | 1.54 (1.06-2.23) | .023 | 27.4 | 1.73 (1.14-2.63) | .011 | ||||||||||
| T-G-C-C | 10.4 | 8.8 | 1.01 (0.73-1.40) | .95 | 9.1 | 1.10 (0.78-1.57) | .58 | 8.8 | 0.81 (0.32-2.00) | .64 | 9.7 | 1.25 (0.77-2.01) | .37 | 6.2 | 0.83 (0.44-1.56) | .57 | ||||||||||
| Global test† | — | — | — | .029 | — | — | .01 | — | — | .97 | — | — | .043 | — | — | .017 | ||||||||||
Pvalues of less than .05 are italicized.
— indicates not applicable.
Order of SNPs comprising the IL10 haplotypes: -3575T>A, -1082A>G, -819C>T, and -592C>A.
Odds ratios and global test are adjusted for age.
Percentages may not add to 100% because of the presence of rare haplotypes not presented in this table.