Association between TH1/TH2 cytokine polymorphisms and common B-cell subtypes of non-Hodgkin lymphoma
. | Diffuse large B-cell lymphoma . | . | . | . | Follicular . | . | . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene name, SNP database ID (nucleotide change) . | No. of controls (%) . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | |||||
IL5 rs2069812 (-745C>T) | ||||||||||||
CC | 273 (49) | 62 (41) | 1.0 | — | 45 (42) | 1.0 | — | |||||
CT | 238 (42) | 66 (44) | 1.26 (0.85-1.86) | .25 | 52 (49) | 1.37 (0.88-2.12) | .17 | |||||
TT | 51 (9) | 23 (15) | 2.28 (1.25-4.15) | .007 | 9 (8) | 1.19 (0.51-2.76) | .69 | |||||
CT or TT | 289 (51) | 89 (59) | 1.41 (0.97-2.04) | .07 | 61 (58) | 1.34 (0.87-2.05) | .18 | |||||
Trend | — | — | — | .012 | — | — | .28 | |||||
NA† | 10 | 1 | — | — | 2 | — | — | |||||
ND‡ | 1 | 2 | — | — | 2 | — | — | |||||
IL10 rs1800871 (-819>T) | ||||||||||||
CC | 329 (57) | 81 (52) | 1.0 | — | 53 (49) | 1.0 | — | |||||
CT | 211 (37) | 67 (43) | 1.33 (0.92-1.93) | .13 | 51 (47) | 1.54 (1.00-2.36) | .047 | |||||
TT | 34 (6) | 7 (5) | 0.92 (0.39-2.17) | .85 | 5 (5) | 1.0 7 (0.40-2.91) | .89 | |||||
CT or TT | 245 (43) | 74 (48) | 1.28 (0.89-1.83) | .18 | 56 (51) | 1.48 (0.98-2.25) | .063 | |||||
Trend | — | — | — | .36 | — | — | .14 | |||||
NA | 4 | 2 | — | — | 1 | — | — | |||||
ND | 3 | 0 | — | — | 1 | — | — | |||||
IL10 rs1800872 (-592C>A) | ||||||||||||
CC | 331 (59) | 82 (54) | 1.0 | — | 55 (50) | 1.0 | — | |||||
AC | 189 (34) | 62 (41) | 1.38 (0.94-2.02) | .10 | 44 (40) | 1.45 (0.93-2.25) | .10 | |||||
AA | 43 (8) | 8 (5) | 0.81 (0.36-1.80) | .61 | 10 (9) | 1.57 (0.74-3.36) | .24 | |||||
AC or AA | 232 (41) | 70 (46) | 1.28 (0.89-1.84) | .19 | 54 (50) | 1.47 (0.97-2.23) | .071 | |||||
Trend | — | — | — | .49 | — | — | .08 | |||||
NA | 5 | 1 | — | — | 0 | — | — | |||||
ND | 13 | 4 | — | — | 1 | — | — | |||||
IL10 rs1800896 (-1082A>G) | ||||||||||||
AA | 184 (31) | 40 (25) | 1.0 | — | 31 (26) | 1.0 | — | |||||
AG | 305 (52) | 80 (50) | 1.19 (0.78-1.82) | .42 | 63 (53) | 1.26 (0.79-2.02) | .34 | |||||
GG | 98 (17) | 40 (25) | 1.80 (1.09-2.99) | .022 | 24 (20) | 1.40 (0.77-2.53) | .27 | |||||
AG or GG | 403 (69) | 120 (75) | 1.34 (0.90-2.00) | .15 | 87 (74) | 1.30 (0.83-2.03) | .26 | |||||
Trend | — | — | — | .027 | — | — | .24 | |||||
NA | 2 | 0 | — | — | 0 | — | — | |||||
ND | 8 | 1 | — | — | 1 | — | — | |||||
IL10 rs1800890 (-3575T>A) | ||||||||||||
TT | 261 (44) | 58 (36) | 1.0 | — | 40 (34) | 1.0 | — | |||||
AT | 280 (47) | 76 (48) | 1.20 (0.82-1.76) | .35 | 60 (51) | 1.44 (0.93-2.23) | .11 | |||||
AA | 56 (9) | 26 (16) | 2.02 (1.17-3.49) | .012 | 18 (15) | 2.03 (1.08-3.81) | .029 | |||||
AT or AA | 336 (56) | 102 (64) | 1.34 (0.93-1.92) | .12 | 78 (66) | 1.54 (1.01-2.34) | .043 | |||||
Trend | — | — | — | .022 | — | — | .02 | |||||
NA | 0 | 0 | — | — | 0 | — | — | |||||
ND | 0 | 1 | — | — | 0 | — | — |
. | Diffuse large B-cell lymphoma . | . | . | . | Follicular . | . | . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene name, SNP database ID (nucleotide change) . | No. of controls (%) . | No. of cases (%) . | Odds ratio (95% CI) . | P . | No. of cases (%) . | Odds ratio (95% CI) . | P . | |||||
IL5 rs2069812 (-745C>T) | ||||||||||||
CC | 273 (49) | 62 (41) | 1.0 | — | 45 (42) | 1.0 | — | |||||
CT | 238 (42) | 66 (44) | 1.26 (0.85-1.86) | .25 | 52 (49) | 1.37 (0.88-2.12) | .17 | |||||
TT | 51 (9) | 23 (15) | 2.28 (1.25-4.15) | .007 | 9 (8) | 1.19 (0.51-2.76) | .69 | |||||
CT or TT | 289 (51) | 89 (59) | 1.41 (0.97-2.04) | .07 | 61 (58) | 1.34 (0.87-2.05) | .18 | |||||
Trend | — | — | — | .012 | — | — | .28 | |||||
NA† | 10 | 1 | — | — | 2 | — | — | |||||
ND‡ | 1 | 2 | — | — | 2 | — | — | |||||
IL10 rs1800871 (-819>T) | ||||||||||||
CC | 329 (57) | 81 (52) | 1.0 | — | 53 (49) | 1.0 | — | |||||
CT | 211 (37) | 67 (43) | 1.33 (0.92-1.93) | .13 | 51 (47) | 1.54 (1.00-2.36) | .047 | |||||
TT | 34 (6) | 7 (5) | 0.92 (0.39-2.17) | .85 | 5 (5) | 1.0 7 (0.40-2.91) | .89 | |||||
CT or TT | 245 (43) | 74 (48) | 1.28 (0.89-1.83) | .18 | 56 (51) | 1.48 (0.98-2.25) | .063 | |||||
Trend | — | — | — | .36 | — | — | .14 | |||||
NA | 4 | 2 | — | — | 1 | — | — | |||||
ND | 3 | 0 | — | — | 1 | — | — | |||||
IL10 rs1800872 (-592C>A) | ||||||||||||
CC | 331 (59) | 82 (54) | 1.0 | — | 55 (50) | 1.0 | — | |||||
AC | 189 (34) | 62 (41) | 1.38 (0.94-2.02) | .10 | 44 (40) | 1.45 (0.93-2.25) | .10 | |||||
AA | 43 (8) | 8 (5) | 0.81 (0.36-1.80) | .61 | 10 (9) | 1.57 (0.74-3.36) | .24 | |||||
AC or AA | 232 (41) | 70 (46) | 1.28 (0.89-1.84) | .19 | 54 (50) | 1.47 (0.97-2.23) | .071 | |||||
Trend | — | — | — | .49 | — | — | .08 | |||||
NA | 5 | 1 | — | — | 0 | — | — | |||||
ND | 13 | 4 | — | — | 1 | — | — | |||||
IL10 rs1800896 (-1082A>G) | ||||||||||||
AA | 184 (31) | 40 (25) | 1.0 | — | 31 (26) | 1.0 | — | |||||
AG | 305 (52) | 80 (50) | 1.19 (0.78-1.82) | .42 | 63 (53) | 1.26 (0.79-2.02) | .34 | |||||
GG | 98 (17) | 40 (25) | 1.80 (1.09-2.99) | .022 | 24 (20) | 1.40 (0.77-2.53) | .27 | |||||
AG or GG | 403 (69) | 120 (75) | 1.34 (0.90-2.00) | .15 | 87 (74) | 1.30 (0.83-2.03) | .26 | |||||
Trend | — | — | — | .027 | — | — | .24 | |||||
NA | 2 | 0 | — | — | 0 | — | — | |||||
ND | 8 | 1 | — | — | 1 | — | — | |||||
IL10 rs1800890 (-3575T>A) | ||||||||||||
TT | 261 (44) | 58 (36) | 1.0 | — | 40 (34) | 1.0 | — | |||||
AT | 280 (47) | 76 (48) | 1.20 (0.82-1.76) | .35 | 60 (51) | 1.44 (0.93-2.23) | .11 | |||||
AA | 56 (9) | 26 (16) | 2.02 (1.17-3.49) | .012 | 18 (15) | 2.03 (1.08-3.81) | .029 | |||||
AT or AA | 336 (56) | 102 (64) | 1.34 (0.93-1.92) | .12 | 78 (66) | 1.54 (1.01-2.34) | .043 | |||||
Trend | — | — | — | .022 | — | — | .02 | |||||
NA | 0 | 0 | — | — | 0 | — | — | |||||
ND | 0 | 1 | — | — | 0 | — | — |
Values adjusted for age and race. P values less than .05 are italicized.
NA indicates no amplification observed; ND, amplification occurred but genotype could not be determined; and —, not applicable.