Genes and single nucleotide polymorphisms (SNPs) evaluated
Gene . | Name . | Chromosome location§ . | SNP database ID . |
|---|---|---|---|
| Th1 | |||
| IFNG | Interferon-gamma | 12q14 | rs1861494,* rs2069705* |
| IFNGR1 | Interferon-gamma receptor 1 | 6q23-q24 | rs3799488* |
| IFNGR2 | Interferon-gamma receptor 2 | 21q22.11 | rs9808753, rs1059293*† |
| IL2 | Interleukin-2 | 4q26-q27 | rs2069762‡ |
| IL7R | Interleukin-7 receptor | 5p13 | rs1494555* |
| IL12A | Interleukin-12 alpha | 3p12-q13.2 | rs568408, rs582054 |
| IL12B | Interleukin-12B | 5q31.1-q33.1 | rs3212227 |
| IL15 | Interleukin-15 | 4q31 | rs10833* |
| IL15RA | Interleukin-15 receptor alpha | 10p15-p14 | rs2296135* |
| LTA | Lymphotoxin-alpha | 6p21.3 | rs909253,‡ rs2239704 |
| TNF | Tumor necrosis factor | 6p21.3 | rs1800629,‡ rs361525, rs1799724 |
| Th2 | |||
| IL4 | Interleukin-4 | 5q31.1 | rs2243250,† rs2243248, rs2070874,† rs2243290,* rs2243268* |
| IL4R | Interleukin-4 receptor | 16p11.2-p12.1 | rs2107356 |
| IL5 | Interleukin-5 | 5q31.1 | rs2069812 |
| IL6 | Interleukin-6 | 7p21 | rs1800795,‡ rs1800797‡ |
| IL10 | Interleukin-10 | 1q31-q32 | rs1800871, rs1800872,‡ rs1800896,‡ rs3024509,* rs3024496,* rs3024491,* rs1800890‡ |
| IL10RA | Interleukin-10 receptor, alpha | 11q23 | rs9610 |
| IL13 | Interleukin-13 | 5q31 | rs20541, rs1800925, rs1295686* |
| JAK3 | Janus kinase 3 | 19p13.1 | rs3008* |
| Th1/Th2 | |||
| CTLA4 | Cytotoxic T-lymphocyte-associated 4 | 2q33 | rs231775*† |
Gene . | Name . | Chromosome location§ . | SNP database ID . |
|---|---|---|---|
| Th1 | |||
| IFNG | Interferon-gamma | 12q14 | rs1861494,* rs2069705* |
| IFNGR1 | Interferon-gamma receptor 1 | 6q23-q24 | rs3799488* |
| IFNGR2 | Interferon-gamma receptor 2 | 21q22.11 | rs9808753, rs1059293*† |
| IL2 | Interleukin-2 | 4q26-q27 | rs2069762‡ |
| IL7R | Interleukin-7 receptor | 5p13 | rs1494555* |
| IL12A | Interleukin-12 alpha | 3p12-q13.2 | rs568408, rs582054 |
| IL12B | Interleukin-12B | 5q31.1-q33.1 | rs3212227 |
| IL15 | Interleukin-15 | 4q31 | rs10833* |
| IL15RA | Interleukin-15 receptor alpha | 10p15-p14 | rs2296135* |
| LTA | Lymphotoxin-alpha | 6p21.3 | rs909253,‡ rs2239704 |
| TNF | Tumor necrosis factor | 6p21.3 | rs1800629,‡ rs361525, rs1799724 |
| Th2 | |||
| IL4 | Interleukin-4 | 5q31.1 | rs2243250,† rs2243248, rs2070874,† rs2243290,* rs2243268* |
| IL4R | Interleukin-4 receptor | 16p11.2-p12.1 | rs2107356 |
| IL5 | Interleukin-5 | 5q31.1 | rs2069812 |
| IL6 | Interleukin-6 | 7p21 | rs1800795,‡ rs1800797‡ |
| IL10 | Interleukin-10 | 1q31-q32 | rs1800871, rs1800872,‡ rs1800896,‡ rs3024509,* rs3024496,* rs3024491,* rs1800890‡ |
| IL10RA | Interleukin-10 receptor, alpha | 11q23 | rs9610 |
| IL13 | Interleukin-13 | 5q31 | rs20541, rs1800925, rs1295686* |
| JAK3 | Janus kinase 3 | 19p13.1 | rs3008* |
| Th1/Th2 | |||
| CTLA4 | Cytotoxic T-lymphocyte-associated 4 | 2q33 | rs231775*† |
According to NCBI's Map View (http://www.ncbi.nlm.nih.gov/mapview/) at the time of publication.
Genotyped in blood-based samples only.
HWE P < .05 in non-Hispanic white controls.
Included in the pooling effort by the InterLymph case-control consortium33 for all non-Hodgkin lymphoma, diffuse large B-cell lymphoma, and follicular lymphoma among white study subjects.