Table 4.

TCR Vβ use by T-cell clones found in the 13 patients studied and by Sézary cell lines



T-cell clones defined by immunoscopy

Expanded T-cell clones phenotypically characterized
TCR Vβ family
PBMC, 13 patients
Skin, 3 patients
Malignant + SCLs
Nonmalignant
Total
1   0   0   0   0   0  
2   1   1   1   0   1  
3   3   0   0   0   0  
4   1   0   0   0   0  
5   2   0   0   0   0  
6   1   0   0   0   0  
7   1   0   1   0   1  
8   2   1   2   0   2  
9   0   0   0   0   0  
11   1   0   1   0   1  
12   0   0   0   0   0  
13   1   0   1   0   1  
14   2   0   0   2   2  
15   2   1   0   0   0  
16   1   1   0   0   0  
17   4   1   1   1   2  
18   1   0   0   0   0  
20   1   0   0   0   0  
21   1   0   0   0   0  
22   2   0   1   2   3  
23   2   0   1   0   1  
24   0   0   0   0   0  
Total
 
28
 
5
 
9
 
5
 
14
 


T-cell clones defined by immunoscopy

Expanded T-cell clones phenotypically characterized
TCR Vβ family
PBMC, 13 patients
Skin, 3 patients
Malignant + SCLs
Nonmalignant
Total
1   0   0   0   0   0  
2   1   1   1   0   1  
3   3   0   0   0   0  
4   1   0   0   0   0  
5   2   0   0   0   0  
6   1   0   0   0   0  
7   1   0   1   0   1  
8   2   1   2   0   2  
9   0   0   0   0   0  
11   1   0   1   0   1  
12   0   0   0   0   0  
13   1   0   1   0   1  
14   2   0   0   2   2  
15   2   1   0   0   0  
16   1   1   0   0   0  
17   4   1   1   1   2  
18   1   0   0   0   0  
20   1   0   0   0   0  
21   1   0   0   0   0  
22   2   0   1   2   3  
23   2   0   1   0   1  
24   0   0   0   0   0  
Total
 
28
 
5
 
9
 
5
 
14
 

Phenotypic characterization of expanded T-cell clones relies on TCR Vβ, CD 158k, and cell-surface VIM expression. For PBMCs, n = 13 patients; for skin, n = 3.

SCLs indicates Sézary cell lines (HUT78 and Pno).

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