Validation of p53-dependent target-gene activation in response to nutlin-3 and fludarabine
. | RT RTPCR . | . | |
|---|---|---|---|
. | Nut . | Flu . | |
| PCNA | 2.5 ± 0.4 | 2.8 ± 0.5 | |
| CDK1A/p21 | 3.3 ± 0.5 | 2.6 ± 0.4 | |
| GDF15 | 6.1 ± 1.7 | 3.1 ± 1.1 | |
| TNFRSF10B/TRAIL-R2 | 2.1 ± 0.6 | nd | |
| TP5313/PIG3 | 2.5 ± 0.7 | nd | |
| GADD45 | 1.8 ± 0.3 | nd | |
| DDB1 | 2.6 ± 0.3 | nd | |
. | RT RTPCR . | . | |
|---|---|---|---|
. | Nut . | Flu . | |
| PCNA | 2.5 ± 0.4 | 2.8 ± 0.5 | |
| CDK1A/p21 | 3.3 ± 0.5 | 2.6 ± 0.4 | |
| GDF15 | 6.1 ± 1.7 | 3.1 ± 1.1 | |
| TNFRSF10B/TRAIL-R2 | 2.1 ± 0.6 | nd | |
| TP5313/PIG3 | 2.5 ± 0.7 | nd | |
| GADD45 | 1.8 ± 0.3 | nd | |
| DDB1 | 2.6 ± 0.3 | nd | |
Nut indicates nutlin-3; Flu, fludarabine; and nd, not determined.