Table 2. Summary statistics for... | American Society of Hematology

Table 2.

Summary statistics for percentage viable cells by nutlin-3 dose level at 48 hours of treatment

	Normal
Dose level	B-CLL	CD19⁺ cells	PBMCs	CD34⁺ cells	BMMCs
Control	100 (100)	100 (100)	100 (100)	100 (100)	100 (100)
0.1 μM	95 ± 9 (98)	100 ± 3 (100)	100 ± 4 (100)	ND	ND
0.3 μM	87 ± 11 (89)	96 ± 6 (98)	98 ± 6 (98)	ND	ND
1 μM	81 ± 12 (84)	88 ± 11 (89)	95 ± 8 (96)	94 ± 5 (94)	91 ± 5 (91)
3.3 μM	75 ± 12 (80)†	86 ± 9 (86)	85 ± 9 (85)	90 ± 6 (90)	88 ± 7 (87)
10 μM	54 ± 15 (53)‡	83 ± 11 (82)	80 ± 10 (79)	87 ± 6 (88)	82 ± 7 (83)

	Normal
Dose level	B-CLL	CD19⁺ cells	PBMCs	CD34⁺ cells	BMMCs
Control	100 (100)	100 (100)	100 (100)	100 (100)	100 (100)
0.1 μM	95 ± 9 (98)	100 ± 3 (100)	100 ± 4 (100)	ND	ND
0.3 μM	87 ± 11 (89)	96 ± 6 (98)	98 ± 6 (98)	ND	ND
1 μM	81 ± 12 (84)	88 ± 11 (89)	95 ± 8 (96)	94 ± 5 (94)	91 ± 5 (91)
3.3 μM	75 ± 12 (80)†	86 ± 9 (86)	85 ± 9 (85)	90 ± 6 (90)	88 ± 7 (87)
10 μM	54 ± 15 (53)‡	83 ± 11 (82)	80 ± 10 (79)	87 ± 6 (88)	82 ± 7 (83)

Data are presented as means ± SD (median) expressed as percent of control, vehicle-treated cultures.

ND indicates not done.

P < .05, B-CLL versus all normal cells.

P < .01, B-CLL versus all normal cells.