Mutation analysis of all patients with NRAS mutations compared with patients with inv(16) and other NRAS mutations
. | All NRAS mutations, no. (%) . | NRASmut with inv(16), no. (%) . | All other NRAS mutations, no. (%) . |
|---|---|---|---|
| Codon 12 | |||
| Gly > Ala | 7 (2.7) | 1 (2.0) | 6 (2.9) |
| Gly > Arg | 2 (0.8) | 0 (0.0) | 2 (1.0) |
| Gly > Asp | 76 (29.6) | 11 (22.0) | 65 (31.4) |
| Gly > Cys | 10 (3.9) | 2 (4.0) | 8 (3.9) |
| Gly > Phe | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gly > Ser | 12 (4.7) | 0 (0.0) | 12 (5.8) |
| Gly > Val | 4 (1.6) | 0 (0.0) | 4 (1.9) |
| Total | 112 (43.6) | 14 (28.0) | 98 (47.3) |
| Codon 13 | |||
| Gly > Ala | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gly > Arg | 5 (1.9) | 2 (4.0) | 3 (1.4) |
| Gly > Asp | 41 (16.0) | 7 (14.0) | 34 (16.4) |
| Gly > Cys | 2 (0.8) | 0 (0.0) | 2 (1.0) |
| Gly > Val | 5 (1.9) | 1 (2.0) | 4 (1.9) |
| Total | 54 (21.0) | 10 (20.0) | 44 (21.3) |
| Codon 61 | |||
| Gln > Arg | 26 (10.1) | 7 (14.0) | 19 (9.2) |
| Gln > Glu | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gln > His | 5 (1.9) | 1 (2.0) | 4 (1.9) |
| Gln > Leu | 9 (3.5) | 0 (0.0) | 9 (4.3) |
| Gln > Lys | 23 (8.9) | 13 (26.0) | 10 (4.8) |
| Total | 64 (24.9) | 21 (42.0) | 43 (20.8) |
| Not sequenced | 27 (10.5) | 5 (10.0) | 22 (10.6) |
| Overall total | 257 (100.0) | 50 (100.0) | 207 (100.0) |
. | All NRAS mutations, no. (%) . | NRASmut with inv(16), no. (%) . | All other NRAS mutations, no. (%) . |
|---|---|---|---|
| Codon 12 | |||
| Gly > Ala | 7 (2.7) | 1 (2.0) | 6 (2.9) |
| Gly > Arg | 2 (0.8) | 0 (0.0) | 2 (1.0) |
| Gly > Asp | 76 (29.6) | 11 (22.0) | 65 (31.4) |
| Gly > Cys | 10 (3.9) | 2 (4.0) | 8 (3.9) |
| Gly > Phe | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gly > Ser | 12 (4.7) | 0 (0.0) | 12 (5.8) |
| Gly > Val | 4 (1.6) | 0 (0.0) | 4 (1.9) |
| Total | 112 (43.6) | 14 (28.0) | 98 (47.3) |
| Codon 13 | |||
| Gly > Ala | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gly > Arg | 5 (1.9) | 2 (4.0) | 3 (1.4) |
| Gly > Asp | 41 (16.0) | 7 (14.0) | 34 (16.4) |
| Gly > Cys | 2 (0.8) | 0 (0.0) | 2 (1.0) |
| Gly > Val | 5 (1.9) | 1 (2.0) | 4 (1.9) |
| Total | 54 (21.0) | 10 (20.0) | 44 (21.3) |
| Codon 61 | |||
| Gln > Arg | 26 (10.1) | 7 (14.0) | 19 (9.2) |
| Gln > Glu | 1 (0.4) | 0 (0.0) | 1 (0.5) |
| Gln > His | 5 (1.9) | 1 (2.0) | 4 (1.9) |
| Gln > Leu | 9 (3.5) | 0 (0.0) | 9 (4.3) |
| Gln > Lys | 23 (8.9) | 13 (26.0) | 10 (4.8) |
| Total | 64 (24.9) | 21 (42.0) | 43 (20.8) |
| Not sequenced | 27 (10.5) | 5 (10.0) | 22 (10.6) |
| Overall total | 257 (100.0) | 50 (100.0) | 207 (100.0) |