Comparison of cytogenetic aberrations and NPM1 and FLT3-ITD mutations in patients with AML (n = 1485)
. | NPM1-mut/FLT3-ITDneg . | NPM1-mut/FLT3-ITDpos . | NPM1-wt/FLT3-ITDpos . | NPM1-wt/FLT3-ITDneg . |
|---|---|---|---|---|
| No. | 244 | 164 | 148 | 929 |
| Unknown, no. (%) | 14 (5.7) | 12 (7.3) | 7 (4.7) | 57 (6.1) |
| Normal, no. (%) | 182 (79.1)† | 142 (93.4)† | 76 (53.9)† | 309 (35.4) |
| Abnormal, no. (%) | 48 (20.9) | 10 (6.6) | 65 (46.1) | 563 (64.6) |
| t(8;21), no. | 2 | 0 | 3 | 52 |
| inv(16)/t(16;16), no. | 2 | 0 | 5 | 60 |
| t(15;17), no. | 0† | 0 | 11 | 36 |
| +8, no. | 11 | 1 | 12 | 100 |
| -7/7q-, no. (%) | 5 | 0 | 3 | 114 |
| -5/5q-, no. (%) | 3 | 0 | 0 | 91 |
| t(6;9), no. | 0 | 0 | 7 | 0 |
| Complex, no.* | 4‡ | 0 | 5 | 176 |
| -X/-Y, no. | 7 | 2 | 2 | 48 |
| FLT3D835/836, no. (%)∥ | 31/204 (15.2)† | 8/133 (6.0) | 9/124 (7.3) | 42/772 (5.4) |
| MLL-PTD, no. (%)∥ | 0/126 (0)† | 0/81 (0)§ | 11/73 (15.1)§ | 28/476 (5.9) |
. | NPM1-mut/FLT3-ITDneg . | NPM1-mut/FLT3-ITDpos . | NPM1-wt/FLT3-ITDpos . | NPM1-wt/FLT3-ITDneg . |
|---|---|---|---|---|
| No. | 244 | 164 | 148 | 929 |
| Unknown, no. (%) | 14 (5.7) | 12 (7.3) | 7 (4.7) | 57 (6.1) |
| Normal, no. (%) | 182 (79.1)† | 142 (93.4)† | 76 (53.9)† | 309 (35.4) |
| Abnormal, no. (%) | 48 (20.9) | 10 (6.6) | 65 (46.1) | 563 (64.6) |
| t(8;21), no. | 2 | 0 | 3 | 52 |
| inv(16)/t(16;16), no. | 2 | 0 | 5 | 60 |
| t(15;17), no. | 0† | 0 | 11 | 36 |
| +8, no. | 11 | 1 | 12 | 100 |
| -7/7q-, no. (%) | 5 | 0 | 3 | 114 |
| -5/5q-, no. (%) | 3 | 0 | 0 | 91 |
| t(6;9), no. | 0 | 0 | 7 | 0 |
| Complex, no.* | 4‡ | 0 | 5 | 176 |
| -X/-Y, no. | 7 | 2 | 2 | 48 |
| FLT3D835/836, no. (%)∥ | 31/204 (15.2)† | 8/133 (6.0) | 9/124 (7.3) | 42/772 (5.4) |
| MLL-PTD, no. (%)∥ | 0/126 (0)† | 0/81 (0)§ | 11/73 (15.1)§ | 28/476 (5.9) |
The number of patients with individual aberrations adds to a higher number than the absolute number of patients with aberrations because several patients had more than one aberration.
Three or more structural or numerical chromosomal aberrations.
P < .01.
P < .001.
P < .05.
No. of positive cases/total cases analyzed.