Mutations in the intracellular domain of Notch1 from T cell lymphomas
Genotype and tumor name . | Mutation in Notch1* . | Consequence of mutation . |
|---|---|---|
| E2A-/- | ||
| Primary | GCAC insertion at nt 7093 | Novel 128 aa starting at aa 2365; deletion of PEST domain |
| 0531 | GG insertion at nt 7194 | Novel 3 aa starting at aa 2398; deletion of PEST domain |
| 0714 | CACT insertion at nt 7020 | Novel 152 aa starting at aa 2341; deletion of PEST domain |
| 1.F9 | C to T mutation at nt 6772 | P to S mutation at aa 2258 |
| p53-/- | ||
| Primary | No mutation | NA |
| 16610D9 | No mutation | NA |
| K052FA2 | No mutation | NA |
| K052FA2C1 | No mutation | NA |
| K052DA20 | No mutation | NA |
| Unknown | ||
| S49.1 | No mutation | NA |
Genotype and tumor name . | Mutation in Notch1* . | Consequence of mutation . |
|---|---|---|
| E2A-/- | ||
| Primary | GCAC insertion at nt 7093 | Novel 128 aa starting at aa 2365; deletion of PEST domain |
| 0531 | GG insertion at nt 7194 | Novel 3 aa starting at aa 2398; deletion of PEST domain |
| 0714 | CACT insertion at nt 7020 | Novel 152 aa starting at aa 2341; deletion of PEST domain |
| 1.F9 | C to T mutation at nt 6772 | P to S mutation at aa 2258 |
| p53-/- | ||
| Primary | No mutation | NA |
| 16610D9 | No mutation | NA |
| K052FA2 | No mutation | NA |
| K052FA2C1 | No mutation | NA |
| K052DA20 | No mutation | NA |
| Unknown | ||
| S49.1 | No mutation | NA |
nt indicates nucleotide; aa, amino acid; and NA, not applicable.
Sequenced nt 4672-7581.