Cytokine levels measured before and after RIC allo-SCT
. | Median level (range) . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cytokine . | Before allo-SCT . | Day 0 . | 1 mo after allo-SCT . | 2 mo after allo-SCT . | 3 mo after allo-SCT . | ||||
| IL-1β, pg/mL | 5 (0-29) | 0 (0-1062) | 0 (0-496) | 0 (0-675) | 0 (0-23) | ||||
| IL-6, pg/mL | 0 (0-265) | 0 (0-63) | 0 (0-667) | 0 (0-13) | 0 (0-411) | ||||
| IL-8, pg/mL | 0 (0-911) | 0 | 0 (0-630) | 0 (0-149) | 0 (0-139) | ||||
| IL-10, pg/mL | 0 (0-51) | 0 (0-142) | 0 (0-71) | 0 (0-124) | 0 (0-664) | ||||
| IL-12p70, pg/mL | 1246 (41-2643) | 768 (0-2831) | 1669 (0-9000) | 885 (0-6790) | 1973 (0-4112) | ||||
| IL-18, pg/mL | 0 (0-452) | 0 (0-1145) | 0 (0-10453) | 0 (0-3579) | 0 (0-20587) | ||||
| IFN-α, pg/mL | 0 | 0 (0-768) | 0 (0-817) | 0 | 0 | ||||
| IFN-γ, pg/mL | 0 (0-39) | 8 (0-225) | 0 (0-478) | 0 (0-167) | 3 (0-240) | ||||
| Fas-ligand, ng/mL | 0 (0-1) | 0 | 0 (0-1) | 0 (0-15) | 0 (0-1) | ||||
| TNF-α, pg/mL | 0 (0-64) | 0 (0-134) | 0 (0-200) | 0 | 0 | ||||
. | Median level (range) . | . | . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cytokine . | Before allo-SCT . | Day 0 . | 1 mo after allo-SCT . | 2 mo after allo-SCT . | 3 mo after allo-SCT . | ||||
| IL-1β, pg/mL | 5 (0-29) | 0 (0-1062) | 0 (0-496) | 0 (0-675) | 0 (0-23) | ||||
| IL-6, pg/mL | 0 (0-265) | 0 (0-63) | 0 (0-667) | 0 (0-13) | 0 (0-411) | ||||
| IL-8, pg/mL | 0 (0-911) | 0 | 0 (0-630) | 0 (0-149) | 0 (0-139) | ||||
| IL-10, pg/mL | 0 (0-51) | 0 (0-142) | 0 (0-71) | 0 (0-124) | 0 (0-664) | ||||
| IL-12p70, pg/mL | 1246 (41-2643) | 768 (0-2831) | 1669 (0-9000) | 885 (0-6790) | 1973 (0-4112) | ||||
| IL-18, pg/mL | 0 (0-452) | 0 (0-1145) | 0 (0-10453) | 0 (0-3579) | 0 (0-20587) | ||||
| IFN-α, pg/mL | 0 | 0 (0-768) | 0 (0-817) | 0 | 0 | ||||
| IFN-γ, pg/mL | 0 (0-39) | 8 (0-225) | 0 (0-478) | 0 (0-167) | 3 (0-240) | ||||
| Fas-ligand, ng/mL | 0 (0-1) | 0 | 0 (0-1) | 0 (0-15) | 0 (0-1) | ||||
| TNF-α, pg/mL | 0 (0-64) | 0 (0-134) | 0 (0-200) | 0 | 0 | ||||
Absence of range indication means that the cytokine was not detected in any patient at the corresponding time point. Cytokine levels were measured by ELISA at regular intervals in the first 3 months after RIC allo-SCT. Median times for cytokine measurements were as follows: before allo-SCT: median, day –7 (range, –23 to –3); day 0, all procedures performed on day 0; 1 month after allo-SCT: median, day 28 (range, days 20-41); 2 months after allo-SCT: median, day 59 (range, days 49-75); and 3 months after allo-SCT: median, day 91 (range, days 76-114).