Table 5.

Pharmacokinetic parameters for dGuo after 8 intravenous infusions of forodesine

Patient no. and dose
Tmax, h
Cmax, μM
AUCall, h · μM
1    
   40 mg/m2  48   34.3   1663  
2    
   40 mg/m2  97   4.3   222  
3    
   40 mg/m2  97   2.6   134  
4    
   40 mg/m2  73   13.9   853  
5    
   40 mg/m2  97   16.9   444  
   40 mg/m2  96   15.9   741  
   60 mg/m2  96   20.1   952  
   90 mg/m2
 		 96
 		 36.8
 		 1164
 
Patient no. and dose
Tmax, h
Cmax, μM
AUCall, h · μM
1    
   40 mg/m2  48   34.3   1663  
2    
   40 mg/m2  97   4.3   222  
3    
   40 mg/m2  97   2.6   134  
4    
   40 mg/m2  73   13.9   853  
5    
   40 mg/m2  97   16.9   444  
   40 mg/m2  96   15.9   741  
   60 mg/m2  96   20.1   952  
   90 mg/m2
 		 96
 		 36.8
 		 1164
 

Tmax indicates time to achieve maximum level; Cmax, maximum observed concentration; AUCall, area under the curve for a single dose over 24-hour period.

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