Invasive aspergillosis in 13 patients who did not receive Aspergillus-specific T-cell therapy
Patient no. . | Invasive aspergillosis . | Galactomannan antigenemia at diagnosis, ng/mL* . | Galactomannan antigenemia under amphotericin therapy,†ng/mL . | Outcome (time after diagnosis, wk) . |
|---|---|---|---|---|
| 1 | P: mult/bilat | 4.5 ± 0.7 | 3.1 ± 0.3 | Death (5) |
| 2 | P: monolat | 3.5 ± 0.6 | 3.6 ± 0.6 | Death (7) |
| 3 | P: mult/bilat | 1.9 ± 0.1 | 1.4 ± 0.1 | Death (4) |
| 4 | P: mult/bilat + pl eff | 4.1 ± 0.2 | 3.3 ± 0.5 | Resolution (17) |
| 5 | P: mult/bilat | 3.1 ± 0.1 | 1.5 ± 0.06 | Resolution (4) |
| 6 | P: mult/bilat | 1.8 ± 0.4 | 2.6 ± 0.6 | Resolution (4) |
| 7 | P: mult/bilat | 4.7 ± 0.4 | 2.7 ± 1.3 | Death (5) |
| 8 | P: mult/bilat | 2.8 ± 0.3 | 2.3 ± 0.8 | Death (4) |
| 9 | P: monolat | 2.9 ± 0.3 | 3.0 ± 0.15 | Resolution (4) |
| 10 | P: monolat + pl eff | 3.9 ± 0.3 | 3.3 ± 0.7 | Resolution (5) |
| 11 | P: monolat + pl eff | 1.8 ± 0.4 | 2.9 ± 0.5 | Death (4) |
| 12 | P: mult/bilat | 2.9 ± 0.2 | 3.3 ± 0.6 | Resolution (5) |
| 13 | P: monolat + pl eff | 3.2 ± 0.2 | 2.8 ± 0.3 | Resolution (6) |
Patient no. . | Invasive aspergillosis . | Galactomannan antigenemia at diagnosis, ng/mL* . | Galactomannan antigenemia under amphotericin therapy,†ng/mL . | Outcome (time after diagnosis, wk) . |
|---|---|---|---|---|
| 1 | P: mult/bilat | 4.5 ± 0.7 | 3.1 ± 0.3 | Death (5) |
| 2 | P: monolat | 3.5 ± 0.6 | 3.6 ± 0.6 | Death (7) |
| 3 | P: mult/bilat | 1.9 ± 0.1 | 1.4 ± 0.1 | Death (4) |
| 4 | P: mult/bilat + pl eff | 4.1 ± 0.2 | 3.3 ± 0.5 | Resolution (17) |
| 5 | P: mult/bilat | 3.1 ± 0.1 | 1.5 ± 0.06 | Resolution (4) |
| 6 | P: mult/bilat | 1.8 ± 0.4 | 2.6 ± 0.6 | Resolution (4) |
| 7 | P: mult/bilat | 4.7 ± 0.4 | 2.7 ± 1.3 | Death (5) |
| 8 | P: mult/bilat | 2.8 ± 0.3 | 2.3 ± 0.8 | Death (4) |
| 9 | P: monolat | 2.9 ± 0.3 | 3.0 ± 0.15 | Resolution (4) |
| 10 | P: monolat + pl eff | 3.9 ± 0.3 | 3.3 ± 0.7 | Resolution (5) |
| 11 | P: monolat + pl eff | 1.8 ± 0.4 | 2.9 ± 0.5 | Death (4) |
| 12 | P: mult/bilat | 2.9 ± 0.2 | 3.3 ± 0.6 | Resolution (5) |
| 13 | P: monolat + pl eff | 3.2 ± 0.2 | 2.8 ± 0.3 | Resolution (6) |
P indicates pneumonia; mult/bilat, multiple, bilateral lung lesions; monolat, monolateral lung lesions; and pl eff, pleural effusion.
Mean ± SD of at least 3 assessments of serum Aspergillus galactomannan antigen levels by sandwich immunocapture ELISA. Values more than 1 ng/mL were considered indicative of invasive aspergillosis
Mean ± SD of weekly assessments for up to 15 weeks after transplantation