Summary of in vitro effects by Shiga toxins and cytokines associated with HUS on cultured endothelial-cell ULVWF string secretion and cleavage by ADAMTS-13
. | ULVWF secretion . | Inhibition of ADAMTS-13 . |
|---|---|---|
| TNF-α | Yes | No |
| IL-8 | Yes | No |
| IL-6 | Yes* | Yes |
| Stx-1 | Yes | Yes |
| Stx-2 | Yes | Yes |
. | ULVWF secretion . | Inhibition of ADAMTS-13 . |
|---|---|---|
| TNF-α | Yes | No |
| IL-8 | Yes | No |
| IL-6 | Yes* | Yes |
| Stx-1 | Yes | Yes |
| Stx-2 | Yes | Yes |
The concentrations of substances used for the in vitro experimental results summarized in this table are greater than the concentrations expected immediately after injection in vivo in the blood of baboons13,32 and greyhounds49 that develop HUS.
IL-6 stimulation of ULVWF string secretion requires the presence of soluble IL-6 receptor67