Hematologic and biochemical data from patients with SCD and HMS.
. | Baseline . | 10 d . | 16 d AMT* . | 30 d . | 107 d . |
|---|---|---|---|---|---|
| Case no. 1 | |||||
| Hct, % | 18.3 | 28.2 | 29.7 | 21.8 | 38.9 |
| Hb, g/L | 49 | 86 | 95 | 65 | 121 |
| HbS, % | 96.6 | ND | ND | ND | ND |
| MCHC, g/L | 269 | 305 | 318 | 298 | 312 |
| PLTs, cells × 109/L | 182 | 216 | 113 | 152 | 217 |
| WBC cells × 109/L | 29.7 | 14.8 | 6.8 | 34.6 | 15.9 |
| QBC | Negative | Negative | Positive | Negative | Negative |
| Blood film | Negative | Negative | Positive | Negative | Negative |
| IgM, g/L† | 30 | ND | ND | 21 | 13 |
| Ab anti-P falciparum | 1/5120 | ND | ND | ND | ND |
| Case no. 2 | |||||
| Hct, % | 19 | 31 | 24 | 26 | 31 |
| Hb, g/L | 59 | 100 | 82 | 84 | 110 |
| HbS, % | 84 | 28 | 47 | 29 | ND |
| MCHC, g/L | 320 | 310 | 310 | 300 | 320 |
| PLTs, cells × 109/L | 107 | 112 | 176 | 154 | 419 |
| WBC cells × 109/L | 6.4 | 11.5 | 8.5 | 9.9 | 3.6 |
| Tbil, mg/dL | 4 | 3.1 | 2.4 | 2 | 1.9 |
| IgM, g/L† | 400 | 430 | 280 | 23 | 37 |
| QBC | ND | Positive | Positive | Negative | ND |
| Blood film | Negative | Positive | Positive | Negative | ND |
| Ab anti-P falciparum | ND | 1/20 480 | ND | ND | ND |
. | Baseline . | 10 d . | 16 d AMT* . | 30 d . | 107 d . |
|---|---|---|---|---|---|
| Case no. 1 | |||||
| Hct, % | 18.3 | 28.2 | 29.7 | 21.8 | 38.9 |
| Hb, g/L | 49 | 86 | 95 | 65 | 121 |
| HbS, % | 96.6 | ND | ND | ND | ND |
| MCHC, g/L | 269 | 305 | 318 | 298 | 312 |
| PLTs, cells × 109/L | 182 | 216 | 113 | 152 | 217 |
| WBC cells × 109/L | 29.7 | 14.8 | 6.8 | 34.6 | 15.9 |
| QBC | Negative | Negative | Positive | Negative | Negative |
| Blood film | Negative | Negative | Positive | Negative | Negative |
| IgM, g/L† | 30 | ND | ND | 21 | 13 |
| Ab anti-P falciparum | 1/5120 | ND | ND | ND | ND |
| Case no. 2 | |||||
| Hct, % | 19 | 31 | 24 | 26 | 31 |
| Hb, g/L | 59 | 100 | 82 | 84 | 110 |
| HbS, % | 84 | 28 | 47 | 29 | ND |
| MCHC, g/L | 320 | 310 | 310 | 300 | 320 |
| PLTs, cells × 109/L | 107 | 112 | 176 | 154 | 419 |
| WBC cells × 109/L | 6.4 | 11.5 | 8.5 | 9.9 | 3.6 |
| Tbil, mg/dL | 4 | 3.1 | 2.4 | 2 | 1.9 |
| IgM, g/L† | 400 | 430 | 280 | 23 | 37 |
| QBC | ND | Positive | Positive | Negative | ND |
| Blood film | Negative | Positive | Positive | Negative | ND |
| Ab anti-P falciparum | ND | 1/20 480 | ND | ND | ND |
Hct indicates hematocrit; Hb, hemoglobin; ND, not determined; HbS, hemoglobin S; MCHC, mean corpuscular hemoglobin concentration; PLTs, platelets; WBC, white blood cells; QBC, quantitative buffy coat; and Ab anti–P falciparum, positive > 1/80.
Starting day for antimalarial treatment
IgM (normal values < 25 g/L)