APLA subtype IgG and IgM titers in SLE patients with and without thrombotic events
. | Median antibody titers*(range) . | . | . | . | |
|---|---|---|---|---|---|
| APLA subtype . | Thombosis positive . | Thrombosis negative . | F value† . | P . | |
| ACLA IgG | 24.0 (4.5-65) | 11.0 (1.0-65) | 6.1 | .017 | |
| ACLA IgM | 31.0 (2.5-100) | 12.0 (2.5-100) | 6.1 | .017 | |
| Anti-β2-GPI IgG | 10.5 (2.7-91) | 3.5 (0-127) | 11.7 | .001 | |
| Anti-β2-GPI IgM | 21.0 (0.3-54) | 4.3 (0.4-78) | 3.9 | .054 | |
| Anti-PT IgG | 23.2 (5.9-135) | 11.7 (1.4-134) | 3.7 | .059 | |
| Anti-PT IgM | 22.0 (3.9-92) | 13.8 (1.2-111) | 0.6 | .453 | |
. | Median antibody titers*(range) . | . | . | . | |
|---|---|---|---|---|---|
| APLA subtype . | Thombosis positive . | Thrombosis negative . | F value† . | P . | |
| ACLA IgG | 24.0 (4.5-65) | 11.0 (1.0-65) | 6.1 | .017 | |
| ACLA IgM | 31.0 (2.5-100) | 12.0 (2.5-100) | 6.1 | .017 | |
| Anti-β2-GPI IgG | 10.5 (2.7-91) | 3.5 (0-127) | 11.7 | .001 | |
| Anti-β2-GPI IgM | 21.0 (0.3-54) | 4.3 (0.4-78) | 3.9 | .054 | |
| Anti-PT IgG | 23.2 (5.9-135) | 11.7 (1.4-134) | 3.7 | .059 | |
| Anti-PT IgM | 22.0 (3.9-92) | 13.8 (1.2-111) | 0.6 | .453 | |
For thrombosis-positive patients, n = 7; for thrombosis-negative patients, n = 51.
ACLA titers are given in IgG phospholipid (GPL) and IgM phospholipid (MPL) units based on standards from the Antiphospholipid Standardization Laboratory, University of Louisville, KY; anti-β2-GPI and anti-PT titers represent percentages of internal standards
The comparison is based on repeated-measures analysis-of-variance accounting for repeat sampling in each patient (initial and follow-up samples), performed on log-transformed values