Table 1. Summary of combination indexes... | American Society of Hematology

Table 1.

Summary of combination indexes (CIs) generated from the isobologram at increasing concentrations of bortezomib and lonafarnib for MM.1R cell line

Combination	Bortezomib (nM)	FA_bort	Lonafarnib (μM)	FA_lona	FA_Comb	CI
1	6 nm	0.522	5	0.570	0.334	0.777
2	8 nm	0.488	5	0.570	0.317	0.366
3	8 nm	0.488	4.5	0.726	0.335	0.717
4	20 nm	0.423	3.5	0.664	0.315	0.607
5	20 nm	0.423	4	0.727	0.157	0.255
6	20 nm	0.423	5	0.570	0.117	0.236

Combination	Bortezomib (nM)	FA_bort	Lonafarnib (μM)	FA_lona	FA_Comb	CI
1	6 nm	0.522	5	0.570	0.334	0.777
2	8 nm	0.488	5	0.570	0.317	0.366
3	8 nm	0.488	4.5	0.726	0.335	0.717
4	20 nm	0.423	3.5	0.664	0.315	0.607
5	20 nm	0.423	4	0.727	0.157	0.255
6	20 nm	0.423	5	0.570	0.117	0.236

CI less than 1.0 indicates synergy, while CI greater than 1.0 indicates antagonism.

FA_bort indicates fraction growth inhibition by bortezomib alone; FA_lona, fraction growth inhibition by lonafarnib alone; and FA_Comb, fraction growth inhibition by bortezomib + lonafarnib.

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