Table 2.

Thrombosis risk for haplotypes of FGG, FGA, and FGB



FGG

FGA

FGB
Haplotype
No. patients (%)
No. controls (%)
OR (95% CI)
No. patients (%)
No. controls (%)
OR (95% CI)
No. patients (%)
No. controls (%)
OR (95% CI)
Haplotype 1          
   H1Hx   222 (47.3)   236 (50.1)   0.8 (0.6-1.1)   192 (41.0)   200 (42.5)   1.0 (0.7-1.3)   212 (45.3)   210 (45.1)   1.1 (0.8-1.4)  
   H1H1   56 (11.9)   65 (13.8)   0.8 (0.5-1.2)   39 (8.3)   33 (7.0)   1.2 (0.7-2.0)   58 (12.4)   50 (10.7)   1.2 (0.8-1.9)  
Haplotype 2          
   H2Hx   201 (42.8)   198 (42.0)   1.2 (0.9-1.5)   200 (42.7)   202 (42.9)   1.1 (0.9-1.5)   165 (35.3)   151 (32.4)   1.2 (0.9-1.6)  
   H2H2   57 (12.2)   28 (6.0)   2.4 (1.5-3.9)   60 (12.8)   34 (7.2)   2.0 (1.3-3.2)   33 (7.1)   19 (4.1)   1.9 (1.1-3.4)  
Haplotype 3          
   H3Hx   185 (39.4)   211 (44.8)   0.8 (0.6-1.0)   85 (18.2)   103 (21.9)   0.8 (0.6-1.1)   78 (16.7)   95 (20.4)   0.8 (0.6-1.1)  
   H3H3   32 (6.8)   39 (8.3)   0.7 (0.4-1.2)   5 (1.1)   7 (1.5)   0.7 (0.2-2.2)   5 (1.1)   5 (1.1)   1.0 (0.3-3.3)  
Haplotype 4          
   H4Hx   38 (8.1)   32 (6.8)   1.2 (0.7-2.0)   94 (20.1)   101 (21.4)   0.9 (0.7-1.2)   119 (25.4)   123 (26.4)   0.9 (0.7-1.3)  
   H4H4   1 (0.2)   0 (0.0)   NA   3 (0.6)   10 (2.1)   0.3 (0.1-1.1)   8 (1.7)   13 (2.8)   0.6 (0.2-1.5)  
Haplotype 5          
   H5Hx   NA   NP   NA   NA   NP   NA   11 (2.4)   16 (3.4)   0.7 (0.3-1.5)  
   H5H5   NA   NP   NA   NA   NP   NA   0 (0.0)   1 (0.2)   NA  
Haplotype 6          
   H6Hx   NA   NA   NA   NA   NP   NA   114 (24.4)   131 (28.1)   0.8 (0.6-1.1)  
   H6H6   NA   NA   NA   NA   NP   NA   7 (1.5)   6 (1.3)   1.1 (0.4-3.3)  
Haplotype 7          
   H7Hx   NA   NA   NA   129 (27.6)   142 (30.1)   0.9 (0.6-1.2)   13 (2.8)   16 (3.4)   0.8 (0.4-1.7)  
   H7H7
 
NA
 
NA
 
NA
 
11 (2.4)
 
13 (2.8)
 
0.8 (0.4-1.9)
 
1 (0.2)
 
1 (0.2)
 
1.0 (0.1-15.9)
 


FGG

FGA

FGB
Haplotype
No. patients (%)
No. controls (%)
OR (95% CI)
No. patients (%)
No. controls (%)
OR (95% CI)
No. patients (%)
No. controls (%)
OR (95% CI)
Haplotype 1          
   H1Hx   222 (47.3)   236 (50.1)   0.8 (0.6-1.1)   192 (41.0)   200 (42.5)   1.0 (0.7-1.3)   212 (45.3)   210 (45.1)   1.1 (0.8-1.4)  
   H1H1   56 (11.9)   65 (13.8)   0.8 (0.5-1.2)   39 (8.3)   33 (7.0)   1.2 (0.7-2.0)   58 (12.4)   50 (10.7)   1.2 (0.8-1.9)  
Haplotype 2          
   H2Hx   201 (42.8)   198 (42.0)   1.2 (0.9-1.5)   200 (42.7)   202 (42.9)   1.1 (0.9-1.5)   165 (35.3)   151 (32.4)   1.2 (0.9-1.6)  
   H2H2   57 (12.2)   28 (6.0)   2.4 (1.5-3.9)   60 (12.8)   34 (7.2)   2.0 (1.3-3.2)   33 (7.1)   19 (4.1)   1.9 (1.1-3.4)  
Haplotype 3          
   H3Hx   185 (39.4)   211 (44.8)   0.8 (0.6-1.0)   85 (18.2)   103 (21.9)   0.8 (0.6-1.1)   78 (16.7)   95 (20.4)   0.8 (0.6-1.1)  
   H3H3   32 (6.8)   39 (8.3)   0.7 (0.4-1.2)   5 (1.1)   7 (1.5)   0.7 (0.2-2.2)   5 (1.1)   5 (1.1)   1.0 (0.3-3.3)  
Haplotype 4          
   H4Hx   38 (8.1)   32 (6.8)   1.2 (0.7-2.0)   94 (20.1)   101 (21.4)   0.9 (0.7-1.2)   119 (25.4)   123 (26.4)   0.9 (0.7-1.3)  
   H4H4   1 (0.2)   0 (0.0)   NA   3 (0.6)   10 (2.1)   0.3 (0.1-1.1)   8 (1.7)   13 (2.8)   0.6 (0.2-1.5)  
Haplotype 5          
   H5Hx   NA   NP   NA   NA   NP   NA   11 (2.4)   16 (3.4)   0.7 (0.3-1.5)  
   H5H5   NA   NP   NA   NA   NP   NA   0 (0.0)   1 (0.2)   NA  
Haplotype 6          
   H6Hx   NA   NA   NA   NA   NP   NA   114 (24.4)   131 (28.1)   0.8 (0.6-1.1)  
   H6H6   NA   NA   NA   NA   NP   NA   7 (1.5)   6 (1.3)   1.1 (0.4-3.3)  
Haplotype 7          
   H7Hx   NA   NA   NA   129 (27.6)   142 (30.1)   0.9 (0.6-1.2)   13 (2.8)   16 (3.4)   0.8 (0.4-1.7)  
   H7H7
 
NA
 
NA
 
NA
 
11 (2.4)
 
13 (2.8)
 
0.8 (0.4-1.9)
 
1 (0.2)
 
1 (0.2)
 
1.0 (0.1-15.9)
 

All odds ratios were calculated with HxHx as the reference category (OR, 1).

Hx indicates all haplotypes but the one given; NA, not applicable; NP, not present in our study.

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