Clinical features of 6 patients with cyclin D1-negative MCL
. | Case no. 1 . | Case no. 2 . | Case no. 3 . | Case no. 4 . | Case no. 5 . | Case no. 6 . |
|---|---|---|---|---|---|---|
| Age, y/sex | 54/F | 61/M | 61/M | 60/M | 54/M | 77/M |
| B symptoms | – | + | – | + | – | – |
| Serum LDH level | Normal | High | Normal | High | Normal | Normal |
| Extranodal sites | BM, PB | BM | BM | BM, spleen | BM | BM, lung, GI |
| IPI score | 2 | 3 | 2 | 3 | 2 | 3 |
| Initial therapy | None | R-CHOP | CHOP | COP | CHOP | COP |
| Response | NA | PR | PR | PR | PR | PR |
| Progression | + | – | + | + | + | + |
| Follow-up, mo | 38 | 5 | 88 | 19 | 70 | 30 |
| Status | AWD | AWD | DOD | AWD | AWD | AWD |
. | Case no. 1 . | Case no. 2 . | Case no. 3 . | Case no. 4 . | Case no. 5 . | Case no. 6 . |
|---|---|---|---|---|---|---|
| Age, y/sex | 54/F | 61/M | 61/M | 60/M | 54/M | 77/M |
| B symptoms | – | + | – | + | – | – |
| Serum LDH level | Normal | High | Normal | High | Normal | Normal |
| Extranodal sites | BM, PB | BM | BM | BM, spleen | BM | BM, lung, GI |
| IPI score | 2 | 3 | 2 | 3 | 2 | 3 |
| Initial therapy | None | R-CHOP | CHOP | COP | CHOP | COP |
| Response | NA | PR | PR | PR | PR | PR |
| Progression | + | – | + | + | + | + |
| Follow-up, mo | 38 | 5 | 88 | 19 | 70 | 30 |
| Status | AWD | AWD | DOD | AWD | AWD | AWD |
All patients were at Ann Arbor stage IV.
LDH indicates lactate dehydrogenase; IPI, International Prognostic Index; BM, bone marrow; PB, peripheral blood; GI, gastrointestinal tract; R, Rituxan; CHOP, cyclophosphamide, doxorubicin, vincristine, and prednisone; COP, cyclophosphamide, vincristine, and prednisone; NA, nonapplicable; PR, partial response; AWD, alive with disease; and DOD, dead of disease.