Pathologic and genetic features of 6 patients with cyclin D1-negative MCL
. | Case no. 1 . | Case no. 2 . | Case no. 3 . | Case no. 4 . | Case no. 5 . | Case no. 6 . |
|---|---|---|---|---|---|---|
| Pathologic features | ||||||
| Growth pattern | Nodular | Diffuse | Nodular | Diffuse | Nodular | Nodular |
| Cytology | Typical | Typical | Typical | Typical | Typical | Typical |
| CD20 | + | + | + | + | + | + |
| CD3 | – | – | – | – | – | – |
| CD5 | + | + | + | + | + | + |
| CD23 | – | – | – | + (w) | – | – |
| CD43 | + (w) | + | – | + | + | + |
| Cyclin D1 | – | – | – | – | – | – |
| Cyclin D2 | + | + | – | – | – | NA |
| Cyclin D3 | – | – | + | + | + | NA |
| Cyclin E | – | – | – | – | – | NA |
| RB | + | + | + | + | + | NA |
| p27Kip1 | – | – | – | – | – | – |
| Genetic features | ||||||
| t(11;14)(q13;q32) | – | – | – | – | – | – |
| 11q13 (cyclin D1) | Normal* | Normal | Normal | Normal | Normal | Normal |
| 12p13 (cyclin D2) | Normal | Normal | Normal | Normal | Normal | Normal |
| 6p21 (cyclin D3) | Normal | Normal | Normal | Normal | Normal | Normal |
| 12p13 (p27kip1) | Normal | Normal | Normal | Normal | Normal | Normal |
. | Case no. 1 . | Case no. 2 . | Case no. 3 . | Case no. 4 . | Case no. 5 . | Case no. 6 . |
|---|---|---|---|---|---|---|
| Pathologic features | ||||||
| Growth pattern | Nodular | Diffuse | Nodular | Diffuse | Nodular | Nodular |
| Cytology | Typical | Typical | Typical | Typical | Typical | Typical |
| CD20 | + | + | + | + | + | + |
| CD3 | – | – | – | – | – | – |
| CD5 | + | + | + | + | + | + |
| CD23 | – | – | – | + (w) | – | – |
| CD43 | + (w) | + | – | + | + | + |
| Cyclin D1 | – | – | – | – | – | – |
| Cyclin D2 | + | + | – | – | – | NA |
| Cyclin D3 | – | – | + | + | + | NA |
| Cyclin E | – | – | – | – | – | NA |
| RB | + | + | + | + | + | NA |
| p27Kip1 | – | – | – | – | – | – |
| Genetic features | ||||||
| t(11;14)(q13;q32) | – | – | – | – | – | – |
| 11q13 (cyclin D1) | Normal* | Normal | Normal | Normal | Normal | Normal |
| 12p13 (cyclin D2) | Normal | Normal | Normal | Normal | Normal | Normal |
| 6p21 (cyclin D3) | Normal | Normal | Normal | Normal | Normal | Normal |
| 12p13 (p27kip1) | Normal | Normal | Normal | Normal | Normal | Normal |
+ indicates positive; –, negative; + (w), weakly positive; and NA, not available.
Normal indicates no split or amplification