Table 1. Cellular composition of... | American Society of Hematology

Table 1.

Cellular composition of leukapheresis products and engraftment data from dogs given 920 cGy TBI followed by transplantation of either autologous or allogeneic AMD3100-mobilized PBMCs

Dog no.	TNC, × 10⁸/kg	CD34, × 10⁶/kg	CD3, × 10⁸/kg	CD4, × 10⁸/kg	CD8, × 10⁸/kg	CD14, × 10⁸/kg	Engraftment	Clinical GVHD	Survival, d	Cause of death
Autologous HCT
G275	15.6	3.3	2.6	1.6	0.6	4.3	Yes	NA	365	End of study
G248	13.2	4.5	2.7	1.6	0.8	2.5	Yes	NA	365	End of study
G294	23.0	8.7	0.6	0.4	0.1	4.2	Yes	NA	365	End of study
G315	4.0	2.0	NE	NE	NE	0.3	Yes	NA	365	End of study
DLA-identical HCT
G383	8.0	2.1	1.4	0.7	0.5	0.6	Yes^*	None	430†	Alive
G378	10.7	6.1	4.4	2.2	1.3	2.6	Yes^*	None	414†	Alive
G422	12.1	4.7	3.6	2.1	1.3	2.7	Yes^*	? Acute S, G	18‡	Pancreatitis, canine HSV
G375	4.5	1.5	2.3	1.2	0.6	1.0	Yes^*	None	324†	Alive
G455	31.4	8.2	0.5	0.4	0.1	2.5	Yes^*	Chronic S	233†	Alive

Dog no.	TNC, × 10⁸/kg	CD34, × 10⁶/kg	CD3, × 10⁸/kg	CD4, × 10⁸/kg	CD8, × 10⁸/kg	CD14, × 10⁸/kg	Engraftment	Clinical GVHD	Survival, d	Cause of death
Autologous HCT
G275	15.6	3.3	2.6	1.6	0.6	4.3	Yes	NA	365	End of study
G248	13.2	4.5	2.7	1.6	0.8	2.5	Yes	NA	365	End of study
G294	23.0	8.7	0.6	0.4	0.1	4.2	Yes	NA	365	End of study
G315	4.0	2.0	NE	NE	NE	0.3	Yes	NA	365	End of study
DLA-identical HCT
G383	8.0	2.1	1.4	0.7	0.5	0.6	Yes^*	None	430†	Alive
G378	10.7	6.1	4.4	2.2	1.3	2.6	Yes^*	None	414†	Alive
G422	12.1	4.7	3.6	2.1	1.3	2.7	Yes^*	? Acute S, G	18‡	Pancreatitis, canine HSV
G375	4.5	1.5	2.3	1.2	0.6	1.0	Yes^*	None	324†	Alive
G455	31.4	8.2	0.5	0.4	0.1	2.5	Yes^*	Chronic S	233†	Alive

TNC indicates total nucleated cell; NA, not applicable; NE, not evaluable; ?, possible; S, skin GVHD; G, gut GVHD; and HSV, herpes simplex virus.

All animals tested had engraftment of donor origin demonstrated by VNTR

†

Alive

‡

Dead

View Large

This Feature Is Available To Subscribers Only