Patient demographics and baseline characteristics
. | Data . |
|---|---|
| No. patients studied | 228 |
| Median age, y (range) | 59 (30-84) |
| Male/female, % | 57/43 |
| Ethnicity, % | |
| European American | 81 |
| African American | 11 |
| Other | 9 |
| Myeloma type, % | |
| IgG | 61 |
| IgA | 24 |
| Other | 15 |
| Median no. of previous regimens (range) | 5 (1-15) |
| Prior therapies, % | |
| Any corticosteroid | 99.6 |
| Any alkylating agent | 89 |
| Any anthracycline | 79 |
| Prior thalidomide | 77 |
| Stem cell transplantation or other high-dose therapy | 61 |
| KPS | |
| No. patients | 222 |
| 70% or less, % of patients | 20 |
| 80%, % of patients | 37 |
| 90% or greater, % of patients | 43 |
| Elevated β2-microglobin level | |
| No. patients | 210 |
| 4 mg/L or greater, % | 44 |
| 6 mg/L or greater, % | 28 |
| Bone marrow cytogenetics | |
| No. patients | 195 |
| Any abnormalities, % | 37 |
| Chromosome 13 deletion, % | 15 |
| Hemoglobin level less than 100 g/L, % | 40 |
| Mean platelet count, × 109/L (median) | 167.2 (166.5) |
| % of patients given platelet transfusions | 14 |
. | Data . |
|---|---|
| No. patients studied | 228 |
| Median age, y (range) | 59 (30-84) |
| Male/female, % | 57/43 |
| Ethnicity, % | |
| European American | 81 |
| African American | 11 |
| Other | 9 |
| Myeloma type, % | |
| IgG | 61 |
| IgA | 24 |
| Other | 15 |
| Median no. of previous regimens (range) | 5 (1-15) |
| Prior therapies, % | |
| Any corticosteroid | 99.6 |
| Any alkylating agent | 89 |
| Any anthracycline | 79 |
| Prior thalidomide | 77 |
| Stem cell transplantation or other high-dose therapy | 61 |
| KPS | |
| No. patients | 222 |
| 70% or less, % of patients | 20 |
| 80%, % of patients | 37 |
| 90% or greater, % of patients | 43 |
| Elevated β2-microglobin level | |
| No. patients | 210 |
| 4 mg/L or greater, % | 44 |
| 6 mg/L or greater, % | 28 |
| Bone marrow cytogenetics | |
| No. patients | 195 |
| Any abnormalities, % | 37 |
| Chromosome 13 deletion, % | 15 |
| Hemoglobin level less than 100 g/L, % | 40 |
| Mean platelet count, × 109/L (median) | 167.2 (166.5) |
| % of patients given platelet transfusions | 14 |
To convert β2-microglobulin level from milligrams per liter to nanomoles per liter, multiply milligrams per liter by 85.
IgG indicates immunoglobulin G.