Table 5. Univariable and multivariable... | American Society of Hematology

Table 5.

Univariable and multivariable analyses of NPM1 mutation as prognostic factor for EFS, DFS, and OS in AML

	EFS			DFS			OS
	HR (95% CI)	P*	HR (95% CI)	P*	HR (95% CI)	P*
Univariable
Intermediate†	2.06 (1.33-3.20)	.001*	2.82 (1.63-4.87)	<.001*	2.67 (1.62-4.41)	<.001*
Poor†	3.88 (2.29-6.56)	<.001*	5.09 (2.61-9.91)	<.001*	4.44 (2.49-7.93)	<.001*
WBC count‡	1.14 (0.84-1.53)	.39	1.18 (0.84-1.68)	.34	1.19 (0.87-1.62)	.29
Age, decades	1.05 (0.94-1.19)	.38	1.06 (0.92-1.22)	.41	1.17 (1.03-1.32)	.014*
FLT3ITD§	1.76 (1.28-2.41)	.001*	1.71 (1.17-2.50)	.006*	1.89 (1.36-2.62)	<.001*
NPM1 mutation∥	0.88 (0.64-1.21)	.43	0.93 (0.64-1.34)	.69	0.90 (0.65-1.27)	.57
Multivariable
Intermediate†	2.18 (1.36-3.50)	.001*	3.11 (1.74-5.55)	<.001*	2.87 (1.69-4.86)	<.001*
Poor†	3.96 (2.34-6.74)	<.001*	5.73 (2.93-11.22)	<.001*	4.68 (2.60-8.43)	<.001*
WBC count‡	1.06 (0.78-1.44)	.72	1.10 (0.77-1.58)	.60	1.18 (0.85-1.63)	.32
Age, decades	1.07 (0.95-1.21)	.27	1.10 (0.95-1.27)	.21	1.19 (1.05-1.35)	.008*
FLT3ITD§	1.96 (1.39-2.76)	<.001*	2.00 (1.31-3.06)	.001*	2.13 (1.49-3.05)	<.001*
NPM1 mutation∥	0.59 (0.41-0.85)	.005*	0.52 (0.34-0.80)	.003*	0.49 (0.33-0.72)	<.001*

	EFS			DFS			OS
	HR (95% CI)	P*	HR (95% CI)	P*	HR (95% CI)	P*
Univariable
Intermediate†	2.06 (1.33-3.20)	.001*	2.82 (1.63-4.87)	<.001*	2.67 (1.62-4.41)	<.001*
Poor†	3.88 (2.29-6.56)	<.001*	5.09 (2.61-9.91)	<.001*	4.44 (2.49-7.93)	<.001*
WBC count‡	1.14 (0.84-1.53)	.39	1.18 (0.84-1.68)	.34	1.19 (0.87-1.62)	.29
Age, decades	1.05 (0.94-1.19)	.38	1.06 (0.92-1.22)	.41	1.17 (1.03-1.32)	.014*
FLT3ITD§	1.76 (1.28-2.41)	.001*	1.71 (1.17-2.50)	.006*	1.89 (1.36-2.62)	<.001*
NPM1 mutation∥	0.88 (0.64-1.21)	.43	0.93 (0.64-1.34)	.69	0.90 (0.65-1.27)	.57
Multivariable
Intermediate†	2.18 (1.36-3.50)	.001*	3.11 (1.74-5.55)	<.001*	2.87 (1.69-4.86)	<.001*
Poor†	3.96 (2.34-6.74)	<.001*	5.73 (2.93-11.22)	<.001*	4.68 (2.60-8.43)	<.001*
WBC count‡	1.06 (0.78-1.44)	.72	1.10 (0.77-1.58)	.60	1.18 (0.85-1.63)	.32
Age, decades	1.07 (0.95-1.21)	.27	1.10 (0.95-1.27)	.21	1.19 (1.05-1.35)	.008*
FLT3ITD§	1.96 (1.39-2.76)	<.001*	2.00 (1.31-3.06)	.001*	2.13 (1.49-3.05)	<.001*
NPM1 mutation∥	0.59 (0.41-0.85)	.005*	0.52 (0.34-0.80)	.003*	0.49 (0.33-0.72)	<.001*

CI indicates confidence interval.

P values < .05.

Cytogenetic risk versus cytogenetic good risk.

More than 20 × 10⁹/L versus less than 20 × 10⁹/L.

FLT3ITD versus no FLT3ITD.

NPM1 mutation versus no NPM1 mutation.