NPM1 mutation-associated gene expression in 275 patients with de novo AML
Probe set ID . | Gene symbol . | Fold change . |
|---|---|---|
| Up-regulated in AML with mutant NPM1 | ||
| 213844_at | HOXA5 | 4.2 |
| 205366_s_at | HOXB6 | 2.6 |
| 208414_s_at | HOXB3 | 1.8 |
| 204082_at | PBX3 | 2.8 |
| 205600_x_at | HOXB5 | 2.1 |
| 206289_at | HOXA4 | 2.1 |
| 205453_at | HOXB2 | 2.1 |
| 213150_at | HOXA10 | 2.6 |
| 204069_at | MEIS1 | 2.6 |
| 209905_at | HOXA9 | 2.8 |
| 201664_at | SMC4L1 | 2.1 |
| 209439_s_at | PHKA2 | 1.6 |
| 206847_s_at | HOXA7 | 1.5 |
| 63825_at | ABHD2 | 1.6 |
| 219304_s_at | PDGFD | 1.9 |
| 212820_at | RC3 | 2.4 |
| 213110_s_at | COL4A5 | 2.9 |
| 207111_at | EMR1 | 2.1 |
| 208557_at | HOXA6 | 1.6 |
| 203471_s_at | PLEK | 1.6 |
| 203680_at | PRKAR2B | 2.3 |
| 202729_s_at | LTBP1 | 3.6 |
| 210145_at | PLA2G4A | 1.6 |
| 220162_s_at | CARD9 | 1.5 |
| 206298_at | ARHGAP22 | 2.0 |
| 219602_s_at | FAM38B | 1.9 |
| Down-regulated in AML with mutant NPM1 | ||
| 209543_s_at | CD34 | -5.4 |
| 206896_s_at | GNG7 | -1.7 |
| 209583_s_at | MOX2 | -3.1 |
| 200953_s_at | CCND2 | -2.1 |
| 221004_s_at | ITM2C | -3.0 |
| 205330_at | MN1 | -4.3 |
| 200602_at | APP | -2.6 |
| 200665_s_at | SPARC | -3.8 |
| 201015_s_at | JUP | -3.1 |
| 218899_s_at | BAALC | -4.3 |
| 209679_s_at | LOC57228 | -1.9 |
| 219694_at | FLJ11127 | -2.1 |
| 206042_x_at | SNRPN | -2.5 |
| 211535_s_at | FGFR1 | -2.6 |
| 214582_at | PDE3B | -1.8 |
| 221523_s_at | RRAGD | -1.8 |
| 213618_at | CENTD1 | -1.7 |
| 218589_at | P2RY5 | -3.3 |
| 202016_at | MEST | -2.9 |
| 208116_s_at | MAN1A1 | -3.1 |
| 205240_at | GPSM2 | -1.9 |
| 202747_s_at | ITM2A | -4.1 |
| 206622_at | TRH | -9.1 |
| 206726_at | PGDS | -4.7 |
Probe set ID . | Gene symbol . | Fold change . |
|---|---|---|
| Up-regulated in AML with mutant NPM1 | ||
| 213844_at | HOXA5 | 4.2 |
| 205366_s_at | HOXB6 | 2.6 |
| 208414_s_at | HOXB3 | 1.8 |
| 204082_at | PBX3 | 2.8 |
| 205600_x_at | HOXB5 | 2.1 |
| 206289_at | HOXA4 | 2.1 |
| 205453_at | HOXB2 | 2.1 |
| 213150_at | HOXA10 | 2.6 |
| 204069_at | MEIS1 | 2.6 |
| 209905_at | HOXA9 | 2.8 |
| 201664_at | SMC4L1 | 2.1 |
| 209439_s_at | PHKA2 | 1.6 |
| 206847_s_at | HOXA7 | 1.5 |
| 63825_at | ABHD2 | 1.6 |
| 219304_s_at | PDGFD | 1.9 |
| 212820_at | RC3 | 2.4 |
| 213110_s_at | COL4A5 | 2.9 |
| 207111_at | EMR1 | 2.1 |
| 208557_at | HOXA6 | 1.6 |
| 203471_s_at | PLEK | 1.6 |
| 203680_at | PRKAR2B | 2.3 |
| 202729_s_at | LTBP1 | 3.6 |
| 210145_at | PLA2G4A | 1.6 |
| 220162_s_at | CARD9 | 1.5 |
| 206298_at | ARHGAP22 | 2.0 |
| 219602_s_at | FAM38B | 1.9 |
| Down-regulated in AML with mutant NPM1 | ||
| 209543_s_at | CD34 | -5.4 |
| 206896_s_at | GNG7 | -1.7 |
| 209583_s_at | MOX2 | -3.1 |
| 200953_s_at | CCND2 | -2.1 |
| 221004_s_at | ITM2C | -3.0 |
| 205330_at | MN1 | -4.3 |
| 200602_at | APP | -2.6 |
| 200665_s_at | SPARC | -3.8 |
| 201015_s_at | JUP | -3.1 |
| 218899_s_at | BAALC | -4.3 |
| 209679_s_at | LOC57228 | -1.9 |
| 219694_at | FLJ11127 | -2.1 |
| 206042_x_at | SNRPN | -2.5 |
| 211535_s_at | FGFR1 | -2.6 |
| 214582_at | PDE3B | -1.8 |
| 221523_s_at | RRAGD | -1.8 |
| 213618_at | CENTD1 | -1.7 |
| 218589_at | P2RY5 | -3.3 |
| 202016_at | MEST | -2.9 |
| 208116_s_at | MAN1A1 | -3.1 |
| 205240_at | GPSM2 | -1.9 |
| 202747_s_at | ITM2A | -4.1 |
| 206622_at | TRH | -9.1 |
| 206726_at | PGDS | -4.7 |
The top 50 unique most discriminating genes and fold change in expression with regard to NPM1 mutation as determined by SAM (up-regulated: increased expression in NPM1 mutant cases; down-regulated: decreased expression in NPM1 mutant cases).