Statistically significant changes in hematological and serum/plasma biochemicals in patients with TDT across transfusion
| Variable and control range . | Before . | After . | Week . | P value . | RBC units . |
|---|---|---|---|---|---|
| Complete blood count | |||||
| Hb (12.0-18.0 g/dL) | 9.7 ± 1.0 | 11.2 ± 1.0∗ | 10.6 ±0.9∗,† | .001 | 17.5 ± 1.7 |
| HCT (37%-52%) | 29.7 ± 3.1 | 34.0 ±3.0∗ | 32.3 ± 3.0∗,† | .001 | 57.3 ± 5.9 |
| RBC (4200 × 109/L to 6100 × 109/L) | 3700 ± 300 | 4200 ± 400∗ | 4000 ± 400∗,† | .001 | 6100 ± 800 |
| MCHC (33-37 g/dL) | 32.5 ± 1.3 | 33.0 ± 0.9∗ | 32.8 ± 1.1∗ | .001 | 30.6 ± 1.8 |
| RETs (50 ×109/L to 100 × 109/L) | 172.7 ± 256.1 | 187.6 ± 232.8∗ | 151.6 ± 201.7∗,† | <.001 | — |
| NRBCs, per 100 WBC | 76.0 ± 126.2 | 69.5 ± 116.1∗ | 35.2 ± 59.1∗,† | <.001 | — |
| WBC (5.2 × 109/L to 12.4 × 109/L) | 9.69 ± 4.20 | 9.76 ± 3.86 | 8.93 ± 4.02∗,† | .019 | 0.08 ± 0.11 |
| Lymphocytes, ×109/L | 2.56 ± 1.22 | 2.84 ± 1.32∗ | 2.67 ± 1.36 | .024 | 0.02 ± 0.04 |
| Monocytes (0.0 × 109/L to 0.8 × 109/L) | 0.74 ± 0.50 | 0.70 ± 0.45 | 0.59 ± 0.36∗,† | .003 | 0.01 ± 0.01 |
| EOSs (0.0 × 109/L to 0.5 × 109/L) | 0.18 ± 0.17 | 0.20 ± 0.17∗ | 0.16 ± 0.13† | .022 | — |
| Basophils (0.0 × 109/L to 0.2 × 109/L) | 0.12 ± 0.11 | 0.13 ± 0.10 | 0.11± 0.09† | .021 | — |
| PLTs (130 × 109/L to 400 × 109/L) | 422 ± 217 | 386 ± 195∗ | 391 ± 212∗ | <.001 | 3.5 ± 3.3 |
| RPR | 0.068 ± 0.066 | 0.070 ± 0.066∗ | 0.071 ± 0.065∗ | .010 | — |
| Serum/plasma biochemicals | |||||
| Hepcidin (0.079-49.4 ng/mL) | 29.2 ± 16.6 | 28.2 ± 16.4 | 29.8 ± 18.8∗ | .038 | — |
| Thrombomodulin (2866-5318 pg/mL) | 4771 ± 3730 | 4684 ± 3410 | 4409 ± 3663∗ | .031 | — |
| aPTT (27-35 s) | 35.9 ± 8.3 | 34.3 ± 8.2∗ | 35.9 ± 8.9 | .019 | — |
| Antithrombin III activity (75%-125% of control) | 90.2 ± 15.0 | 89.7 ± 15.5 | 91.4 ± 17.0∗,† | .049 | — |
| ADAMTS13:Ag (370-1403 ng/mL) | 1009 ± 354 | 1080 ± 354∗ | 1135 ± 481∗ | .034 | — |
| Variable and control range . | Before . | After . | Week . | P value . | RBC units . |
|---|---|---|---|---|---|
| Complete blood count | |||||
| Hb (12.0-18.0 g/dL) | 9.7 ± 1.0 | 11.2 ± 1.0∗ | 10.6 ±0.9∗,† | .001 | 17.5 ± 1.7 |
| HCT (37%-52%) | 29.7 ± 3.1 | 34.0 ±3.0∗ | 32.3 ± 3.0∗,† | .001 | 57.3 ± 5.9 |
| RBC (4200 × 109/L to 6100 × 109/L) | 3700 ± 300 | 4200 ± 400∗ | 4000 ± 400∗,† | .001 | 6100 ± 800 |
| MCHC (33-37 g/dL) | 32.5 ± 1.3 | 33.0 ± 0.9∗ | 32.8 ± 1.1∗ | .001 | 30.6 ± 1.8 |
| RETs (50 ×109/L to 100 × 109/L) | 172.7 ± 256.1 | 187.6 ± 232.8∗ | 151.6 ± 201.7∗,† | <.001 | — |
| NRBCs, per 100 WBC | 76.0 ± 126.2 | 69.5 ± 116.1∗ | 35.2 ± 59.1∗,† | <.001 | — |
| WBC (5.2 × 109/L to 12.4 × 109/L) | 9.69 ± 4.20 | 9.76 ± 3.86 | 8.93 ± 4.02∗,† | .019 | 0.08 ± 0.11 |
| Lymphocytes, ×109/L | 2.56 ± 1.22 | 2.84 ± 1.32∗ | 2.67 ± 1.36 | .024 | 0.02 ± 0.04 |
| Monocytes (0.0 × 109/L to 0.8 × 109/L) | 0.74 ± 0.50 | 0.70 ± 0.45 | 0.59 ± 0.36∗,† | .003 | 0.01 ± 0.01 |
| EOSs (0.0 × 109/L to 0.5 × 109/L) | 0.18 ± 0.17 | 0.20 ± 0.17∗ | 0.16 ± 0.13† | .022 | — |
| Basophils (0.0 × 109/L to 0.2 × 109/L) | 0.12 ± 0.11 | 0.13 ± 0.10 | 0.11± 0.09† | .021 | — |
| PLTs (130 × 109/L to 400 × 109/L) | 422 ± 217 | 386 ± 195∗ | 391 ± 212∗ | <.001 | 3.5 ± 3.3 |
| RPR | 0.068 ± 0.066 | 0.070 ± 0.066∗ | 0.071 ± 0.065∗ | .010 | — |
| Serum/plasma biochemicals | |||||
| Hepcidin (0.079-49.4 ng/mL) | 29.2 ± 16.6 | 28.2 ± 16.4 | 29.8 ± 18.8∗ | .038 | — |
| Thrombomodulin (2866-5318 pg/mL) | 4771 ± 3730 | 4684 ± 3410 | 4409 ± 3663∗ | .031 | — |
| aPTT (27-35 s) | 35.9 ± 8.3 | 34.3 ± 8.2∗ | 35.9 ± 8.9 | .019 | — |
| Antithrombin III activity (75%-125% of control) | 90.2 ± 15.0 | 89.7 ± 15.5 | 91.4 ± 17.0∗,† | .049 | — |
| ADAMTS13:Ag (370-1403 ng/mL) | 1009 ± 354 | 1080 ± 354∗ | 1135 ± 481∗ | .034 | — |
Repeated measures ANOVA or Friedman (Wilcoxon) tests. For hepcidin, n = 19; for aPTT, n = 22.
ADAMTS13:Ag, ADAMTS13 antigen; aPTT, activated partial thromboplastin time; EOSs, eosinophils; HCT, hematocrit; MCHC, mean corpuscular Hb concentration; PLTs, platelets; RDW, red cell distribution width; RPR, the ratio of (RDW × 100) to (platelets).
P < .05 vs before.
P < .05 vs after.