Univariate and multivariate analysis of prognostic factors associated with survival (OS2) of R/R MCL after brexu-cel failure, relapsed set
| Prognostic factors . | Univariate model . | MCL relapsed set, N = 61 . | ||||
|---|---|---|---|---|---|---|
| Multivariate model∗ . | ||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age at infusion | 1.018 | 0.984-1.054 | .2971 | |||
| Number of previous lines >2 | 1.025 | 0.481-2.184 | .9489 | |||
| Number of previous lines >3 | 0.922 | 0.467-1.818 | .8138 | |||
| Not responder to bridging | 3.743 | 1.834-7.640 | .0003 | 5.637 | 2.403-13.223 | < .0001 |
| Ann Arbor stage in class III-IV | 0.790 | 0.168-3.725 | .7663 | |||
| TP53 mutation | 1.312 | 0.590-2.918 | .5048 | |||
| Ki-67 (%) ≥30% | 3.235 | 0.958-10.918 | .0586 | |||
| POD24 | 0.352 | 0.108-1.150 | .0840 | |||
| Bulky disease | 1.406 | 0.708-2.794 | .3305 | |||
| High MIPI risk at infusion (≥6.2) | 4.850 | 1.708-13.773 | .0030 | |||
| ECOG PS at infusion ≥2 | 2.600 | 1.232-5.490 | .0122 | 2.496 | 1.143-5.448 | .0217 |
| LDH (IU/L) at infusion more than the upper limit | 1.325 | 0.668-2.629 | .4205 | |||
| Blastoid variant | 1.718 | 0.856-3.450 | .1278 | |||
| CRS | 1.765 | 0.685-4.547 | .2390 | |||
| Neurotoxicity | 1.562 | 0.810-3.014 | .1835 | |||
| Prognostic factors . | Univariate model . | MCL relapsed set, N = 61 . | ||||
|---|---|---|---|---|---|---|
| Multivariate model∗ . | ||||||
| HR . | 95% CI . | P value . | HR . | 95% CI . | P value . | |
| Age at infusion | 1.018 | 0.984-1.054 | .2971 | |||
| Number of previous lines >2 | 1.025 | 0.481-2.184 | .9489 | |||
| Number of previous lines >3 | 0.922 | 0.467-1.818 | .8138 | |||
| Not responder to bridging | 3.743 | 1.834-7.640 | .0003 | 5.637 | 2.403-13.223 | < .0001 |
| Ann Arbor stage in class III-IV | 0.790 | 0.168-3.725 | .7663 | |||
| TP53 mutation | 1.312 | 0.590-2.918 | .5048 | |||
| Ki-67 (%) ≥30% | 3.235 | 0.958-10.918 | .0586 | |||
| POD24 | 0.352 | 0.108-1.150 | .0840 | |||
| Bulky disease | 1.406 | 0.708-2.794 | .3305 | |||
| High MIPI risk at infusion (≥6.2) | 4.850 | 1.708-13.773 | .0030 | |||
| ECOG PS at infusion ≥2 | 2.600 | 1.232-5.490 | .0122 | 2.496 | 1.143-5.448 | .0217 |
| LDH (IU/L) at infusion more than the upper limit | 1.325 | 0.668-2.629 | .4205 | |||
| Blastoid variant | 1.718 | 0.856-3.450 | .1278 | |||
| CRS | 1.765 | 0.685-4.547 | .2390 | |||
| Neurotoxicity | 1.562 | 0.810-3.014 | .1835 | |||
CRS, cytokine release syndrome; LDH, lactate dehydrogenase.
Multivariate analysis was performed on 49 of 61 patients with available data.