Outcomes of R/R MCL after brexu-cel failure according to salvage therapy
| . | Len/R2 . | CT/ICT . | BTKi/Ven . | TCE . | Other targeted therapy . | Radiation . |
|---|---|---|---|---|---|---|
| Response rate | ||||||
| ORR, n (%) | 3 (18.8%) | 3 (23.1%) | 0 | 3 (42.9%) | 0 | 1 (50%) |
| CR, n (%) | 3 (18.8%) | 2 (15.4%) | 0 | 3 (42.9%) | 0 | 1 (50%) |
| PR, n (%) | 0 | 1 (7.7%) | 0 | 0 | 0 | 0 |
| PFS | ||||||
| Median (95% CI), mo | 2 (0.7-4.4) | 1.1 (0.7-7.5) | 1.7 (1.1-3.1) | 1.5 (0.9-NA) | 2.7 (2.4-NA) | NR (2.4-NR) |
| 6 months (95% CI), % | 23.4 (5.7-47.9) | 30.8 (9.5-55.4) | 0 | 42.9 (9.8-73.4) | 0 | 50 (0.6-91) |
| 12 months (95% CI), % | 15.6 (2.5-39.1) | 23.1 (5.6-47.5) | 0 | 42.9 (9.8-73.4) | 0 | 50 (0.6-91) |
| OS | ||||||
| Median (95% CI), mo | 6.7 (2- NA) | 5.8 (1.5-NA) | 2.8 (1.4-4) | NR (3.3-NA) | 9.6 (7.7-NA) | 11.3 (NA-NA) |
| 6 months (95% CI), % | 44.9 (17.7-69) | 56.3 (27.2-77.6) | 0 | 71.4 (25.8-92) | 0 | 100 (NA-NA) |
| 12 months (95% CI), % | 36.2 (10.8-62.8) | 35.9 (11.7-61.3) | 0 | 57.1 (17.2-83.7) | 0 | 0 |
| . | Len/R2 . | CT/ICT . | BTKi/Ven . | TCE . | Other targeted therapy . | Radiation . |
|---|---|---|---|---|---|---|
| Response rate | ||||||
| ORR, n (%) | 3 (18.8%) | 3 (23.1%) | 0 | 3 (42.9%) | 0 | 1 (50%) |
| CR, n (%) | 3 (18.8%) | 2 (15.4%) | 0 | 3 (42.9%) | 0 | 1 (50%) |
| PR, n (%) | 0 | 1 (7.7%) | 0 | 0 | 0 | 0 |
| PFS | ||||||
| Median (95% CI), mo | 2 (0.7-4.4) | 1.1 (0.7-7.5) | 1.7 (1.1-3.1) | 1.5 (0.9-NA) | 2.7 (2.4-NA) | NR (2.4-NR) |
| 6 months (95% CI), % | 23.4 (5.7-47.9) | 30.8 (9.5-55.4) | 0 | 42.9 (9.8-73.4) | 0 | 50 (0.6-91) |
| 12 months (95% CI), % | 15.6 (2.5-39.1) | 23.1 (5.6-47.5) | 0 | 42.9 (9.8-73.4) | 0 | 50 (0.6-91) |
| OS | ||||||
| Median (95% CI), mo | 6.7 (2- NA) | 5.8 (1.5-NA) | 2.8 (1.4-4) | NR (3.3-NA) | 9.6 (7.7-NA) | 11.3 (NA-NA) |
| 6 months (95% CI), % | 44.9 (17.7-69) | 56.3 (27.2-77.6) | 0 | 71.4 (25.8-92) | 0 | 100 (NA-NA) |
| 12 months (95% CI), % | 36.2 (10.8-62.8) | 35.9 (11.7-61.3) | 0 | 57.1 (17.2-83.7) | 0 | 0 |
N, number; NA, not applicable; NR, not reached.