Baseline characteristics of the included patients
| Characteristic . | Fresher (N = 12 308) . | Older (N = 20 651) . |
|---|---|---|
| Age, y | 68 (56-78) | 68 (56-78) |
| Male sex, n (%) | 6270 (50.9) | 10 389 (50.3) |
| In ICU at randomization, n (%) | 6842 (55.6) | 10 021 (48.5) |
| Patients undergoing surgery, n (%) | 3691/7632 (48.4) | 5771/11 144 (51.8) |
| Cardiothoracic surgery, n (%) | 1337/7637 (17.5) | 2195/11 150 (19.7) |
| ABO group, n (%) | ||
| A | 4952 (40.2) | 8285/20 650 (40.1) |
| AB | 470 (3.8) | 790/20 650 (3.8) |
| B | 1462 (11.9) | 2483/20 650 (12.0) |
| O | 5424 (44.1) | 9092/20 650 (44.0) |
| Coexisting disorders, n (%) | ||
| Cardiovascular disease | 1945/7634 (25.5) | 3349/11 142 (30.1) |
| Myocardial infarction | 368/4090 (9.0) | 379/4123 (9.2) |
| Heart failure | 1658/5242 (31.6) | 3059/8747 (35.0) |
| Diabetes | 1348/5242 (25.7) | 2202/8747 (25.2) |
| Stroke | 102/5242 (1.9) | 102/8747 (1.2) |
| Hemoglobin level at randomization, g/dL | 7.6 (7.0-8.6) | 7.6 (7.0-8.6) |
| Mechanical ventilation at randomization, n (%) | 3528/7636 (46.2) | 4722/11 150 (42.3) |
| Renal replacement therapy at randomization, n (%) | 665/7635 (8.7) | 760/11 150 (6.8) |
| Vasopressor at randomization, n (%) | 1954/4082 (47.9) | 2019/4125 (48.9) |
| Characteristic . | Fresher (N = 12 308) . | Older (N = 20 651) . |
|---|---|---|
| Age, y | 68 (56-78) | 68 (56-78) |
| Male sex, n (%) | 6270 (50.9) | 10 389 (50.3) |
| In ICU at randomization, n (%) | 6842 (55.6) | 10 021 (48.5) |
| Patients undergoing surgery, n (%) | 3691/7632 (48.4) | 5771/11 144 (51.8) |
| Cardiothoracic surgery, n (%) | 1337/7637 (17.5) | 2195/11 150 (19.7) |
| ABO group, n (%) | ||
| A | 4952 (40.2) | 8285/20 650 (40.1) |
| AB | 470 (3.8) | 790/20 650 (3.8) |
| B | 1462 (11.9) | 2483/20 650 (12.0) |
| O | 5424 (44.1) | 9092/20 650 (44.0) |
| Coexisting disorders, n (%) | ||
| Cardiovascular disease | 1945/7634 (25.5) | 3349/11 142 (30.1) |
| Myocardial infarction | 368/4090 (9.0) | 379/4123 (9.2) |
| Heart failure | 1658/5242 (31.6) | 3059/8747 (35.0) |
| Diabetes | 1348/5242 (25.7) | 2202/8747 (25.2) |
| Stroke | 102/5242 (1.9) | 102/8747 (1.2) |
| Hemoglobin level at randomization, g/dL | 7.6 (7.0-8.6) | 7.6 (7.0-8.6) |
| Mechanical ventilation at randomization, n (%) | 3528/7636 (46.2) | 4722/11 150 (42.3) |
| Renal replacement therapy at randomization, n (%) | 665/7635 (8.7) | 760/11 150 (6.8) |
| Vasopressor at randomization, n (%) | 1954/4082 (47.9) | 2019/4125 (48.9) |
Data are median (quartile 25th–quartile 75th) or n/N (%).
ICU, intensive care unit.