Impact of suPAR levels at day +7 on OS based on a Cox model
| Factor . | HR . | 95% CI . | P value . |
|---|---|---|---|
| Day +7 suPAR∗ | — | — | .0005 |
| ≤2.48 | 1.00 | — | — |
| >2.48 | 4.78 | 1.97-11.61 | .0005 |
| GVHD prophylaxis | — | — | .2758 |
| CD34, or selection/posttransplant cyclophosphamide with other(s) | 1.00 | — | — |
| Tacrolimus alone or with others | 0.49 | 0.10-2.37 | .3761 |
| Cyclosporine alone or with others | 0.22 | 0.02-1.88 | .1652 |
| Others | 0.05 | 0.00-1.26 | .0691 |
| Factor . | HR . | 95% CI . | P value . |
|---|---|---|---|
| Day +7 suPAR∗ | — | — | .0005 |
| ≤2.48 | 1.00 | — | — |
| >2.48 | 4.78 | 1.97-11.61 | .0005 |
| GVHD prophylaxis | — | — | .2758 |
| CD34, or selection/posttransplant cyclophosphamide with other(s) | 1.00 | — | — |
| Tacrolimus alone or with others | 0.49 | 0.10-2.37 | .3761 |
| Cyclosporine alone or with others | 0.22 | 0.02-1.88 | .1652 |
| Others | 0.05 | 0.00-1.26 | .0691 |
The above model is stratified by pairing status. The optimal cut point of 2.48 was selected based on the maximum likelihood in fitting the conditional logistic regression model for AKI-D.
The HR of 1.97 (95% CI, 1.26-3.09; P = .0029) when day +7 suPAR is treated as a continuous variable.