Post-HSCT outcomes in pair-matched patients
| Outcomes . | Matched patients . | DDX41 WT (n = 77) . | DDX41 MUT (n = 32) . | P value . |
|---|---|---|---|---|
| Estimation (95% CI) . | Estimation (95% CI) . | Estimation (95% CI) . | ||
| Median FU, y | 6.1 (5-7.1) | 6.2 (5-7.1) | 5.9 (3.4-8) | |
| OS (2 years) | 62 (52.2-70.4) | 61.7 (49.8-71.6) | 62.5 (43.5-76.7) | .91 |
| OS (6 years) | 55.1 (44.9-64.2) | 54.2 (42-64.8) | 56.8 (36.5-72.8) | |
| LFS (2 years) | 59.5 (49.6-68) | 58.2 (46.3-68.3) | 62.5 (43.5-76.7) | .84 |
| LFS (6 years) | 51.1 (40.9-60.5) | 52.1 (40.1-62.7) | 47.9 (27.8-65.5) | |
| RI (2 years) | 21.2 (14-29.3) | 27.5 (17.9-37.8) | 6.2 (1.1-18.4) | .07 |
| RI (6 years) | 26.3 (18-35.3) | 29 (19.2-39.5) | 20.8 (6.9-39.8) | |
| NRM (2 years) | 19.3 (12.5-27.2) | 14.4 (7.6-23.2) | 31.2 (16.1-47.6) | .19 |
| NRM (6 years) | 22.6 (15.1-31) | 18.9 (10.9-28.7) | 31.2 (16.1-47.6) | |
| aGVHD-II/IV (100 days) | 24.8 (17.1-33.2) | 27.3 (17.8-37.6) | 18.8 (7.5-34) | .33 |
| aGVHD-III/IV (100 days) | 8.3 (4-14.4) | 7.8 (3.2-15.2) | 9.4 (2.3-22.5) | .79 |
| cGVHD (2 years) | 37.7 (28.6-46.8) | 40.4 (29.3-51.2) | 31.2 (16-47.8) | .34 |
| cGVHD (6 years) | 37.7 (28.6-46.8) | 40.4 (29.3-51.2) | 31.2 (16-47.8) | |
| cGVHD Ext (2 years) | 14.3 (8.4-21.8) | 18.7 (10.8-28.4) | 3.3 (0.2-14.9) | .07 |
| cGVHD Ext (6 years) | 14.3 (8.4-21.8) | 18.7 (10.8-28.4) | 3.3 (0.2-14.9) |
| Outcomes . | Matched patients . | DDX41 WT (n = 77) . | DDX41 MUT (n = 32) . | P value . |
|---|---|---|---|---|
| Estimation (95% CI) . | Estimation (95% CI) . | Estimation (95% CI) . | ||
| Median FU, y | 6.1 (5-7.1) | 6.2 (5-7.1) | 5.9 (3.4-8) | |
| OS (2 years) | 62 (52.2-70.4) | 61.7 (49.8-71.6) | 62.5 (43.5-76.7) | .91 |
| OS (6 years) | 55.1 (44.9-64.2) | 54.2 (42-64.8) | 56.8 (36.5-72.8) | |
| LFS (2 years) | 59.5 (49.6-68) | 58.2 (46.3-68.3) | 62.5 (43.5-76.7) | .84 |
| LFS (6 years) | 51.1 (40.9-60.5) | 52.1 (40.1-62.7) | 47.9 (27.8-65.5) | |
| RI (2 years) | 21.2 (14-29.3) | 27.5 (17.9-37.8) | 6.2 (1.1-18.4) | .07 |
| RI (6 years) | 26.3 (18-35.3) | 29 (19.2-39.5) | 20.8 (6.9-39.8) | |
| NRM (2 years) | 19.3 (12.5-27.2) | 14.4 (7.6-23.2) | 31.2 (16.1-47.6) | .19 |
| NRM (6 years) | 22.6 (15.1-31) | 18.9 (10.9-28.7) | 31.2 (16.1-47.6) | |
| aGVHD-II/IV (100 days) | 24.8 (17.1-33.2) | 27.3 (17.8-37.6) | 18.8 (7.5-34) | .33 |
| aGVHD-III/IV (100 days) | 8.3 (4-14.4) | 7.8 (3.2-15.2) | 9.4 (2.3-22.5) | .79 |
| cGVHD (2 years) | 37.7 (28.6-46.8) | 40.4 (29.3-51.2) | 31.2 (16-47.8) | .34 |
| cGVHD (6 years) | 37.7 (28.6-46.8) | 40.4 (29.3-51.2) | 31.2 (16-47.8) | |
| cGVHD Ext (2 years) | 14.3 (8.4-21.8) | 18.7 (10.8-28.4) | 3.3 (0.2-14.9) | .07 |
| cGVHD Ext (6 years) | 14.3 (8.4-21.8) | 18.7 (10.8-28.4) | 3.3 (0.2-14.9) |