Table 2.

Response at 4 GBV induction cycles

Lugano CT scan based  n % 90% CI 
Overall response 33 46.5 36.30-56.89 
CR 14 19.7 12.33-29.1 
PR 19 26.7 18.29-36.75 
Stable disease 5.6 1.95-12.43 
Progressive disease 27 38.0 28.37-48.46 
Death 4.2 1.16-10.56 
Nonevaluable  5.6 1.95-12.43 
Lugano PET scan based n % 90% CI 
Overall metabolic response 32 45.1 34.96-55.50 
Complete metabolic response 17 23.9 15.87-33.72 
Partial metabolic response 15 21.1 13.50-30.65 
Progressive metabolic disease 11 15.5 8.94-24.34 
Missing  28 39.4 29.68-49.88 
Lugano CT scan based  n % 90% CI 
Overall response 33 46.5 36.30-56.89 
CR 14 19.7 12.33-29.1 
PR 19 26.7 18.29-36.75 
Stable disease 5.6 1.95-12.43 
Progressive disease 27 38.0 28.37-48.46 
Death 4.2 1.16-10.56 
Nonevaluable  5.6 1.95-12.43 
Lugano PET scan based n % 90% CI 
Overall metabolic response 32 45.1 34.96-55.50 
Complete metabolic response 17 23.9 15.87-33.72 
Partial metabolic response 15 21.1 13.50-30.65 
Progressive metabolic disease 11 15.5 8.94-24.34 
Missing  28 39.4 29.68-49.88 

Primary end point.

Related to premature withdrawal for early PD (n = 3) or for AE after 1 cycle (n = 1)

Related to overt (clinically and/or on CT scan) disease progression (no PET-CT done; n = 21), deaths (n = 3), premature withdrawal after 4 cycles for adverse event (n = 2), or other reason (n = 2).

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