Table 3.

Competing risk analysis after DLI: impact of donor source as a covariate

VariablesaGVHDcGVHD
HR (95% CI)P valueHR (95% CI)P value
Age at transplant 0.99 (0.93-1.06) .83 0.97 (0.90-1.06) .53 
Transplant year     
2005-2009 (reference)     
2010-2015 1.21 (0.48-3.08) .68 0.81 (0.24-2.72) .74 
2016-2021 1.57 (0.63-3.92) .34 1.15 (0.35-3.75) .82 
Diagnosis     
ALL (reference)     
AML 2.12 (0.81-5.49) .12 2.68 (0.74-9.79) .14 
Other leukemias 2.50 (0.77-8.12) .13 2.10 (0.34-12.97) .50 
Nonmalignant 0.84 (0.24-3.03) .80 0.46 (0.05-3.95) .48 
Days from HCT to DLI 0.98 (0.96-0.99) <.001 0.99 (0.97-1.00) .06 
CD3+ cell dose (first DLI) 0.93 (0.84-1.03) .17 1.03 (0.98-1.09) .21 
Cell source     
PBSC (reference)     
BM 0.41 (0.07-2.38) .32 1.13 (0.10-12.90) .92 
VariablesaGVHDcGVHD
HR (95% CI)P valueHR (95% CI)P value
Age at transplant 0.99 (0.93-1.06) .83 0.97 (0.90-1.06) .53 
Transplant year     
2005-2009 (reference)     
2010-2015 1.21 (0.48-3.08) .68 0.81 (0.24-2.72) .74 
2016-2021 1.57 (0.63-3.92) .34 1.15 (0.35-3.75) .82 
Diagnosis     
ALL (reference)     
AML 2.12 (0.81-5.49) .12 2.68 (0.74-9.79) .14 
Other leukemias 2.50 (0.77-8.12) .13 2.10 (0.34-12.97) .50 
Nonmalignant 0.84 (0.24-3.03) .80 0.46 (0.05-3.95) .48 
Days from HCT to DLI 0.98 (0.96-0.99) <.001 0.99 (0.97-1.00) .06 
CD3+ cell dose (first DLI) 0.93 (0.84-1.03) .17 1.03 (0.98-1.09) .21 
Cell source     
PBSC (reference)     
BM 0.41 (0.07-2.38) .32 1.13 (0.10-12.90) .92 

P values <.05 are in bold font.

ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; BM, bone marrow; PBSC, peripheral blood stem cells.

Adjusted for transplant type.

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