Regression estimates for hemoglobin increments after RBC transfusion (N = 6220)
| Characteristic . | Hemoglobin increment (95% CI), g/dL∗ . | P value . |
|---|---|---|
| Donor metabolite characteristics | ||
| Hypoxanthine | –0.10 (–0.18 to –0.02) | .01 |
| HETE | –0.03 (–0.07 to 0.01) | .13 |
| Urate | –0.05 (–0.12 to –0.01) | .04 |
| l-Citrulline | 0.05 (0.01-0.12) | .04 |
| Donor genetic characteristics | ||
| SLC7A5 (kynurenine: RS8052118) | –0.09 (–0.17 to 0.01) | .04 |
| P53 (HETE: RS80649467) | –0.13 (–0.22 to –0.04) | .01 |
| ABCG2 (urate: RS138409370) | –0.13 (–0.29 to –0.03) | .04 |
| Irradiation + PFKP (hypoxanthine: RS2388595) | –0.15 (–0.27 to –0.03) | .01 |
| Characteristic . | Hemoglobin increment (95% CI), g/dL∗ . | P value . |
|---|---|---|
| Donor metabolite characteristics | ||
| Hypoxanthine | –0.10 (–0.18 to –0.02) | .01 |
| HETE | –0.03 (–0.07 to 0.01) | .13 |
| Urate | –0.05 (–0.12 to –0.01) | .04 |
| l-Citrulline | 0.05 (0.01-0.12) | .04 |
| Donor genetic characteristics | ||
| SLC7A5 (kynurenine: RS8052118) | –0.09 (–0.17 to 0.01) | .04 |
| P53 (HETE: RS80649467) | –0.13 (–0.22 to –0.04) | .01 |
| ABCG2 (urate: RS138409370) | –0.13 (–0.29 to –0.03) | .04 |
| Irradiation + PFKP (hypoxanthine: RS2388595) | –0.15 (–0.27 to –0.03) | .01 |
Multivariable regression estimates estimating the mean hemoglobin increment after transfusion with 95% CIs accounting for the blood donor, product, and transfusion recipient covariates in Table 1.